Tolulope T Sajobi1, Kathy N Speechley2, Zhiying Liang3, Shane W Goodwin4, Mark A Ferro5, Samuel Wiebe6. 1. Department of Community Health Sciences & O'Brien Institute for Public Health, University of Calgary, Calgary, Canada; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. Electronic address: tolu.sajobi@ucalgary.ca. 2. Department of Paediatrics, Western University, London, Canada; Department of Epidemiology & Biostatistics, Western University, London, Canada. 3. Department of Community Health Sciences & O'Brien Institute for Public Health, University of Calgary, Calgary, Canada. 4. Department of Epidemiology & Biostatistics, Western University, London, Canada. 5. School of Public Health & Health Systems, Waterloo, Canada. 6. Department of Community Health Sciences & O'Brien Institute for Public Health, University of Calgary, Calgary, Canada; Department of Clinical Neurosciences & Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Abstract
OBJECTIVE: Diagnosis of epilepsy is known to impact health-related quality of life (HRQOL) of children with new-onset epilepsy and can also influence their conceptualization and valuation of HRQOL construct, also known as response shift. This study investigates the presence of response shift in a cohort of children with new-onset epilepsy. METHODS: Data are from the HEalth-Related QUality of Life in children with Epilepsy Study, a prospective cohort study of 373 children with new-onset epilepsy. Hypotheses about the presence of reconceptualization, reprioritization, and recalibration response shift were tested in the Quality of Life in Childhood Epilepsy (QOLCE-55) Questionnaire, a parent-reported, disease-specific HRQOL measure, using Oort's structural equation model between baseline and 1-year follow-up. Model fit was assessed using log-likelihood ratio test, root mean square error of approximation, and comparative fit index. RESULTS: Small positive uniform recalibration response shift effects were observed on physical, emotional, and social functioning domains of the QOLCE-55, but negligibly small negative nonuniform recalibration response shift effect was observed on social functioning domain. There was no significant change in overall QOLCE-55 scores over time after adjusting for response shift effects. SIGNIFICANCE: Parents of children with new-onset epilepsy are likely to positively recalibrate (upward bias) their assessments of their children's HRQOL over a 1-year period after diagnosis. This study highlights the potential benefits of response shift as a desired consequence in parents' perception of changes in HRQOL of children with new-onset epilepsy.
OBJECTIVE: Diagnosis of epilepsy is known to impact health-related quality of life (HRQOL) of children with new-onset epilepsy and can also influence their conceptualization and valuation of HRQOL construct, also known as response shift. This study investigates the presence of response shift in a cohort of children with new-onset epilepsy. METHODS: Data are from the HEalth-Related QUality of Life in children with Epilepsy Study, a prospective cohort study of 373 children with new-onset epilepsy. Hypotheses about the presence of reconceptualization, reprioritization, and recalibration response shift were tested in the Quality of Life in Childhood Epilepsy (QOLCE-55) Questionnaire, a parent-reported, disease-specific HRQOL measure, using Oort's structural equation model between baseline and 1-year follow-up. Model fit was assessed using log-likelihood ratio test, root mean square error of approximation, and comparative fit index. RESULTS: Small positive uniform recalibration response shift effects were observed on physical, emotional, and social functioning domains of the QOLCE-55, but negligibly small negative nonuniform recalibration response shift effect was observed on social functioning domain. There was no significant change in overall QOLCE-55 scores over time after adjusting for response shift effects. SIGNIFICANCE: Parents of children with new-onset epilepsy are likely to positively recalibrate (upward bias) their assessments of their children's HRQOL over a 1-year period after diagnosis. This study highlights the potential benefits of response shift as a desired consequence in parents' perception of changes in HRQOL of children with new-onset epilepsy.
Authors: Neethi P Pinto; Robert A Berg; Athena F Zuppa; Christopher J Newth; Murray M Pollack; Kathleen L Meert; Mark W Hall; Michael Quasney; Anil Sapru; Joseph A Carcillo; Patrick S McQuillen; Peter M Mourani; Ranjit S Chima; Richard Holubkov; Vinay M Nadkarni; Ron W Reeder; Jerry J Zimmerman Journal: Front Pediatr Date: 2021-08-18 Impact factor: 3.569
Authors: Leontien C C Toussaint-Duyster; Monique H M van der Cammen-van Zijp; Dick Tibboel; Saskia Gischler; Joost van Rosmalen; Hanneke IJsselstijn Journal: Acta Paediatr Date: 2020-02-22 Impact factor: 2.299