Literature DB >> 28843158

Development of bone seeker radiopharmaceuticals by Scandium-47 and estimation of human absorbed dose.

Leila Deilami-Nezhad1, Leila Moghaddam-Banaem2, Mahdi Sadeghi3.   

Abstract

In this study labeling EDTMP (ethylenediamine tetra(methylene phosphonic acid)) and HEDP (Hydroxyethylidene-1, 1-Diphosphonic Acid) as the carrier ligands with Scandium-47 were investigated. The biokinetics of the bone seeking of labeled ligands with Scandium-47 were assessed by measuring the skeletal absorbed dose and then the mice data extrapolated to human absorbed dose and compared with the 186/188Rhenium-HEDP, 153Samarium-EDTMP dosimetry data estimated by other researchers. Because the availability of 47Sc was limited we performed some preliminary studies using 46Sc.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  (47/46)Sc-EDTMP; (47/46)Sc-HEDP; Biodistribution; Human dosimetry; Radiopharmaceuticals

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Substances：

Year:  2017        PMID： 28843158     DOI： 10.1016/j.apradiso.2017.07.062

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  2 in total

Review 1.  Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements.

Authors:  R Mikolajczak; S Huclier-Markai; C Alliot; F Haddad; D Szikra; V Forgacs; P Garnuszek
Journal:  EJNMMI Radiopharm Chem       Date:  2021-05-25

2.  The Preparation, Biodistribution, and Dosimetry of Encapsulated Radio-Scandium in a Dendrimer for Radio-nano-pharmaceutical Application.

Authors:  Leila Moghaddam-Banaem; Navideh Aghaei Amirkhizi; Sodeh Sadjadi; Fariba Johari-Deha; Mitra Athari-Allaf
Journal:  Iran J Pharm Res       Date:  2022-05-08       Impact factor: 1.962
  2 in total

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