Sara Poletti1, Veronica Aggio2, Silvia Brioschi3, Irene Bollettini4, Andrea Falini5, Cristina Colombo3, Francesco Benedetti2. 1. Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy; C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy. Electronic address: poletti.sara@hsr.it. 2. Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy; C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy. 3. Scientific Institute and University Vita-Salute San Raffaele, Department of Clinical Neurosciences, Milan, Italy. 4. C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy; PhD Program in Philosophy and Sciences of Mind, University Vita-Salute San Raffaele, Milan, Italy. 5. C.E.R.M.A.C. (Centro di Eccellenza Risonanza Magnetica ad Alto Campo), University Vita-Salute San Raffaele, Milan, Italy; Scientific Institute and University Vita-Salute San Raffaele, Department of Neuroradiology, Milan, Italy.
Abstract
BACKGROUND: Major Depressive Disorder (MDD) is a worldwide-spread pathology, characterized by lifetime-recurrent episodes. Adverse childhood experiences (ACE) increase the lifetime risk of developing depression and affect the structure of the brain. Recent stressful events (RSE) can trigger the onset of depressive episodes, and affect grey matter volume. The aim of our study is to analyse the effect of both early and recent stress events on white matter microstructure in MDD patients and healthy volunteers. METHODS: Sixty-five MDD inpatients and fifty-nine healthy controls underwent MRI acquisition of diffusion tensor images with a 3.0T scanner. Severity of ACE and RSE was rated, respectively, on the Risky Families Questionnaire and on the Social Readjustment Rating Scale. RESULTS: A significant effect of diagnosis was observed, with MDD subjects showing reduced fractional anisotropy (FA) and axial diffusivity (AD) compared to healthy controls in all the major association, projection and commissural tracts. In patients with MDD, but not in healthy controls, both ACE and RSE correlated with measures of WM microstructure: ACE correlated negatively with AD and MD, whereas RSE correlated negatively with FA. LIMITATIONS: The two diagnostic groups differed for age and education, previous and current medications, and treatment periods. CONCLUSIONS: Exposure to both early and recent stress exerts a widespread effect on WM microstructure of MDD patients, with a different impact possibly depending from the developmental period in which the stress has occurred.
BACKGROUND: Major Depressive Disorder (MDD) is a worldwide-spread pathology, characterized by lifetime-recurrent episodes. Adverse childhood experiences (ACE) increase the lifetime risk of developing depression and affect the structure of the brain. Recent stressful events (RSE) can trigger the onset of depressive episodes, and affect grey matter volume. The aim of our study is to analyse the effect of both early and recent stress events on white matter microstructure in MDDpatients and healthy volunteers. METHODS: Sixty-five MDD inpatients and fifty-nine healthy controls underwent MRI acquisition of diffusion tensor images with a 3.0T scanner. Severity of ACE and RSE was rated, respectively, on the Risky Families Questionnaire and on the Social Readjustment Rating Scale. RESULTS: A significant effect of diagnosis was observed, with MDD subjects showing reduced fractional anisotropy (FA) and axial diffusivity (AD) compared to healthy controls in all the major association, projection and commissural tracts. In patients with MDD, but not in healthy controls, both ACE and RSE correlated with measures of WM microstructure: ACE correlated negatively with AD and MD, whereas RSE correlated negatively with FA. LIMITATIONS: The two diagnostic groups differed for age and education, previous and current medications, and treatment periods. CONCLUSIONS: Exposure to both early and recent stress exerts a widespread effect on WM microstructure of MDDpatients, with a different impact possibly depending from the developmental period in which the stress has occurred.
Authors: Gladi Thng; Xueyi Shen; Aleks Stolicyn; Mathew A Harris; Mark J Adams; Miruna C Barbu; Alex S F Kwong; Sophia Frangou; Stephen M Lawrie; Andrew M McIntosh; Liana Romaniuk; Heather C Whalley Journal: Eur Psychiatry Date: 2022-07-28 Impact factor: 7.156