Literature DB >> 2884303

Tamoxifen inhibits 5-lipoxygenase in human polymorphonuclear leucocytes.

I A Tavares, I F Stamford, A Bennett.   

Abstract

Breast cancer patient survival is increased by tamoxifen, and we therefore need to understand how this drug exerts its effect. We describe a novel action of tamoxifen, the inhibition of LTB4 and 5-HETE production from [14C]-arachidonic acid by human polymorphonuclear leucocytes.

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Year:  1987        PMID: 2884303     DOI: 10.1111/j.2042-7158.1987.tb06279.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN: 0022-3573            Impact factor:   3.765


  1 in total

1.  Efficacy of tamoxifen for the treatment of severe equine asthma.

Authors:  Sophie Mainguy-Seers; Khristine Picotte; Jean-Pierre Lavoie
Journal:  J Vet Intern Med       Date:  2018-08-07       Impact factor: 3.333

  1 in total

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