Literature DB >> 28842982

Novel Therapeutic Targets Against Spreading Depression.

Shih-Pin Chen1,2,3,4, Cenk Ayata1,5.   

Abstract

Migraine is among the most prevalent and disabling neurological diseases in the world. Cortical spreading depression (SD) is an intense wave of neuronal and glial depolarization underlying migraine aura, and a headache trigger, which has been used as an experimental platform for drug screening in migraine. Here, we provide an overview of novel therapeutic targets that show promise to suppress SD, such as acid-sensing ion channels, casein kinase Iδ, P2X7-pannexin 1 complex, and neuromodulation, and outline the experimental models and essential quality measures for rigorous and reproducible efficacy testing.
© 2017 American Headache Society.

Entities:  

Keywords:  aura; cortical spreading depression; ion channels; migraine; neuromodulation; susceptibility

Mesh：

Substances：

Year:  2017        PMID： 28842982     DOI： 10.1111/head.13154

Source DB:  PubMed          Journal:  Headache        ISSN： 0017-8748            Impact factor:   5.887


  8 in total

1.  Mechanisms of the negative potential associated with Leão's spreading depolarization: A history of brain electrogenesis.

Authors:  Oscar Herreras; Julia Makarova
Journal:  J Cereb Blood Flow Metab       Date:  2020-06-24       Impact factor: 6.200

2.  Circulating Insulin-Like Growth Factor 1 Levels and Migraine Risk: A Mendelian Randomization Study.

Authors:  Reziya Abuduxukuer; Peng-Peng Niu; Zhen-Ni Guo; Yu-Ming Xu; Yi Yang
Journal:  Neurol Ther       Date:  2022-09-01

Review 3.  Animal Models of Chronic Migraine.

Authors:  Tse-Ming Chou; Shih-Pin Chen
Journal:  Curr Pain Headache Rep       Date:  2018-05-19

4.  Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.

Authors:  Zachariah Bertels; Harinder Singh; Isaac Dripps; Kendra Siegersma; Alycia F Tipton; Wiktor D Witkowski; Zoie Sheets; Pal Shah; Catherine Conway; Elizaveta Mangutov; Mei Ao; Valentina Petukhova; Bhargava Karumudi; Pavel A Petukhov; Serapio M Baca; Mark M Rasenick; Amynah A Pradhan
Journal:  Elife       Date:  2021-04-15       Impact factor: 8.140

Review 5.  Molecular Communication of a Dying Neuron in Stroke.

Authors:  Berta Puig; Santra Brenna; Tim Magnus
Journal:  Int J Mol Sci       Date:  2018-09-19       Impact factor: 5.923

Review 6.  Spreading depression as a preclinical model of migraine.

Authors:  Andrea M Harriott; Tsubasa Takizawa; David Y Chung; Shih-Pin Chen
Journal:  J Headache Pain       Date:  2019-05-02       Impact factor: 7.277

7.  Migraine and peripheral pain models show differential alterations in neuronal complexity.

Authors:  Zachariah Bertels; Elizaveta Mangutov; Catherine Conway; Kendra Siegersma; Sarah Asif; Pal Shah; Nolan Huck; Vivianne L Tawfik; Amynah A Pradhan
Journal:  Headache       Date:  2022-07-13       Impact factor: 5.311

8.  Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.

Authors:  Isaac J Dripps; Zachariah Bertels; Laura S Moye; Alycia F Tipton; Kendra Siegersma; Serapio M Baca; Brigitte L Kieffer; Amynah A Pradhan
Journal:  Sci Rep       Date:  2020-10-19       Impact factor: 4.996
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.