Persistent Gram-negative Neurosurgical Meningitis in a Neonate, Successfully Treated With Intraventricular Colistin: Case Report and Review of the Literature.

We present a case of Gram-negative neurosurgical meningitis in a neonate, refractory to optimal intravenous therapy and removal of ventriculoperitoneal shunt. Cerebrospinal fluid was sterilized within 24 hours using intraventricular colistin. This is the first report of intraventricular colistin use in neonatal meningitis caused by Enterobacter cloacae.