Literature DB >> 2884122

Stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor from cultured endothelial cells.

A Mülsch, E Böhme, R Busse.   

Abstract

Bovine endothelial cells, grown on microcarrier beads and superfused with a saline solution, were stimulated with thimerosal or bradykinin to release endothelium-derived relaxing factor (EDRF). EDRF activity in the effluent was assayed in endothelium-denuded rabbit aorta. The stimulation of purified soluble guanylate cyclase in test tubes by the EDRF-containing effluent amounted to 90-fold of basal activity and its time course correlated with that of the dilator response of the aorta. After preincubation of endothelial cells with gossypol the EDRF-induced dilator response as well as the stimulation of guanylate cyclase was suppressed.

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Year:  1987        PMID： 2884122     DOI： 10.1016/0014-2999(87)90620-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  18 in total

Review 1.  Endothelial cells as part of a vascular oxygen-sensing system: hypoxia-induced release of autacoids.

Authors:  U Pohl
Journal:  Experientia       Date:  1990-12-01

2.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Authors:  L J Ignarro; G M Buga; K S Wood; R E Byrns; G Chaudhuri
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  Comparison of relaxation responses of vascular and non-vascular smooth muscle to endothelium-derived relaxing factor (EDRF), acidified sodium nitrite (NO) and sodium nitroprusside.

Authors:  T M Cocks; J A Angus
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-04       Impact factor: 3.000

4.  Nitric oxide synthesis in endothelial cytosol: evidence for a calcium-dependent and a calcium-independent mechanism.

Authors:  A Mülsch; E Bassenge; R Busse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

5.  Simultaneous measurement of endothelium-derived relaxing factor by bioassay and guanylate cyclase stimulation.

Authors:  K Kondo; J A Mitchell; G de Nucci; J R Vane
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

6.  Endothelium- and sydnonimine-induced responses of native and cultured aortic smooth muscle cells are not impaired by nitroglycerin tolerance.

Authors:  A Mülsch; R Busse; I Winter; E Bassenge
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

7.  NG-nitro-L-arginine (N5-[imino(nitroamino)methyl]-L-ornithine) impairs endothelium-dependent dilations by inhibiting cytosolic nitric oxide synthesis from L-arginine.

Authors:  A Mülsch; R Busse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

8.  Endothelium-derived relaxant factor inhibits platelet activation.

Authors:  R Busse; A Lückhoff; E Bassenge
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

9.  Differential role of extra- and intracellular calcium in the release of EDRF and prostacyclin from cultured endothelial cells.

Authors:  A Lückhoff; U Pohl; A Mülsch; R Busse
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

10.  Alkaline buffers release EDRF from bovine cultured aortic endothelial cells.

Authors:  J A Mitchell; G de Nucci; T D Warner; J R Vane
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739
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