Xingwei Gu1, Rong Jin2, Xuping Mao1, Jun Wang3, Jintao Yuan4, Guodong Zhao1. 1. Department of General Surgery, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, PR China. 2. Department of Obstetrics & Gynecology, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, PR China. 3. Department of General Surgery, The Second People's Hospital of Taizhou, Taizhou 225300, PR China. 4. Department of Clinical Laboratory, Danyang People's Hospital of Jiangsu Province, Danyang affiliated Hospital of Nantong University, Danyang 213000, RP China.
Abstract
AIMS: miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients. MATERIALS & METHODS: Studies were systemically searched from publications and analyzed, and 999 CRC cases in nine studies were examined in this meta-analysis. RESULTS: Hazard ratio for overall survival of high miR-181a and miR-181b expression in CRC was 1.65. More prominent predictive effects were observed in black people, miR-181b group and small-sample-size group. CONCLUSION: High levels of miR-181a and miR-181b predict poor overall survival in CRC patients. miR-181a and miR-181b are promising biomarkers for CRC prognosis.
AIMS: miR-181a and miR-181b have been investigated as prognostic biomarkers of colorectal cancer (CRC). However, there is controversy about the role of miR-181a and miR-181b in predicting CRC prognosis. Therefore, we performed this meta-analysis to evaluate prognostic values of miR-181a and miR-181b in CRC patients. MATERIALS & METHODS: Studies were systemically searched from publications and analyzed, and 999 CRC cases in nine studies were examined in this meta-analysis. RESULTS: Hazard ratio for overall survival of high miR-181a and miR-181b expression in CRC was 1.65. More prominent predictive effects were observed in black people, miR-181b group and small-sample-size group. CONCLUSION: High levels of miR-181a and miR-181b predict poor overall survival in CRC patients. miR-181a and miR-181b are promising biomarkers for CRC prognosis.