Literature DB >> 2884051

Induction of gamma-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver.

C A Power, S A Griffiths, J L Simpson, Y Laperche, G Guellaen, M M Manson.   

Abstract

We have studied the induction of rat liver gamma-glutamyl transpeptidase (GGT) mRNA by the antioxidant ethoxyquin and during aflatoxin B1-induced carcinogenesis. Using a rat kidney GGT cDNA probe, Northern blot analysis revealed that GGT mRNA induced in liver by either compounds was slightly larger than that found in untreated kidney. GGT mRNA was not detected in untreated liver or freshly isolated hepatocytes, but induction of the message in treated tissues correlated with the increase in enzymic activity observed by histochemistry and quantitative assay. Slot-blot analysis of poly(A)+ mRNA indicated that constitutive GGT mRNA levels in kidney were at least 5-fold greater than those in the most GGT-positive liver-derived tissue examined.

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Year:  1987        PMID： 2884051     DOI： 10.1093/carcin/8.5.737

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  6 in total

1.  Differential expression of the rat gamma-glutamyl transpeptidase gene promoters along with differentiation of hepatoblasts into biliary or hepatocytic lineage.

Authors:  N Holic; T Suzuki; A Corlu; D Couchie; M N Chobert; C Guguen-Guillouzo; Y Laperche
Journal:  Am J Pathol       Date:  2000-08       Impact factor: 4.307

2.  Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat gamma-glutamyl transpeptidase gene.

Authors:  J H Baik; S Siegrist; G Giuili; O Lahuna; F Bulle; G Guellaën
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

3.  Regulation of mouse mammary-gland gamma-glutamyltranspeptidase mRNA during pregnancy, lactation and weaning.

Authors:  S Siegrist; Y Laperche; M N Chobert; F Bulle; H L Nakhasi; G Guellaën
Journal:  Biochem J       Date:  1990-05-01       Impact factor: 3.857

4.  Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.

Authors:  N Heisterkamp; E Rajpert-De Meyts; L Uribe; H J Forman; J Groffen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

5.  The gamma-glutamyl transpeptidase gene is transcribed from a different promoter in rat hepatocytes and biliary cells.

Authors:  A Brouillet; N Holic; M N Chobert; Y Laperche
Journal:  Am J Pathol       Date:  1998-04       Impact factor: 4.307

6.  Expression of multiple gamma-glutamyltransferase genes in man.

Authors:  C Courtay; N Heisterkamp; G Siest; J Groffen
Journal:  Biochem J       Date:  1994-02-01       Impact factor: 3.857
  6 in total

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