Sabine K Maschke1, Thomas Werncke1, Roman Klöckner2, Thomas Rodt1, Julius Renne1, Martha M Kirstein3, Arndt Vogel3, Frank K Wacker1, Bernhard C Meyer1, Jan B Hinrichs4,5. 1. Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany. 2. Department of Diagnostic and Interventional Radiology, Johannes Gutenberg-University Medical Centre, Mainz, Germany. 3. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. 4. Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany. hinrichs.jan@mh-hannover.de. 5. Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. hinrichs.jan@mh-hannover.de.
Abstract
PURPOSE: To analyze the feasibility of 2D-perfusion angiography (2D-PA) for the quantification of perfusion reduction following transarterial chemoembolization with drug-eluting beads (DEB-TACE). METHODS: Overall, 24 DEB-TACE procedures in 19 patients were included. To quantify changes in tumor perfusion following DEB-TACE using 2D-PA, the acquired digital subtraction angiography (DSA) series were post-processed. A reference region-of-interest (ROI) in a main hepatic artery and two, distal target ROIs in embolized tumor tissue and in non-target liver parenchyma were placed in corresponding areas on DSA pre- and post-DEB-TACE. The time to peak (TTP), peak density (PD), and the area under the curve (AUC) were assessed and the ratios reference ROI/target ROIs were calculated. RESULTS: In the embolized tumor, the 2D-PA ratios changed significantly (p < 0.05) after DEB-TACE, whereas no significant change was observed for non-target liver parenchyma (p > 0.05). PDtumor/PDinflow differed significantly to PDparenchyma/PDinflow pre-DEB-TACE (p < 0.0001), likewise AUCtumor/AUCinflow to AUCparenchyma/AUCinflow (p < 0.0001) with higher values in tumor tissue. The post-DEB-TACE ratios of AUC decreased significantly in the tumor tissue compared to the non-target liver parenchyma (p < 0.05). CONCLUSION: 2D-PA offers an objective approach to quantify the immediate perfusion reduction of embolized tumor tissue following DEB-TACE and may therefore be used to monitor peri-interventional stasis and to quantify technical success.
PURPOSE: To analyze the feasibility of 2D-perfusion angiography (2D-PA) for the quantification of perfusion reduction following transarterial chemoembolization with drug-eluting beads (DEB-TACE). METHODS: Overall, 24 DEB-TACE procedures in 19 patients were included. To quantify changes in tumor perfusion following DEB-TACE using 2D-PA, the acquired digital subtraction angiography (DSA) series were post-processed. A reference region-of-interest (ROI) in a main hepatic artery and two, distal target ROIs in embolized tumor tissue and in non-target liver parenchyma were placed in corresponding areas on DSA pre- and post-DEB-TACE. The time to peak (TTP), peak density (PD), and the area under the curve (AUC) were assessed and the ratios reference ROI/target ROIs were calculated. RESULTS: In the embolized tumor, the 2D-PA ratios changed significantly (p < 0.05) after DEB-TACE, whereas no significant change was observed for non-target liver parenchyma (p > 0.05). PDtumor/PDinflow differed significantly to PDparenchyma/PDinflow pre-DEB-TACE (p < 0.0001), likewise AUCtumor/AUCinflow to AUCparenchyma/AUCinflow (p < 0.0001) with higher values in tumor tissue. The post-DEB-TACE ratios of AUC decreased significantly in the tumor tissue compared to the non-target liver parenchyma (p < 0.05). CONCLUSION:2D-PA offers an objective approach to quantify the immediate perfusion reduction of embolized tumor tissue following DEB-TACE and may therefore be used to monitor peri-interventional stasis and to quantify technical success.
Authors: Katsuyuki Taguchi; Thomas J Sauer; W Paul Segars; Eric C Frey; Jingyan Xu; Eleni Liapi; J Webster Stayman; Kelvin Hong; Ferdinand K Hui; Mathias Unberath; Yong Du Journal: Med Phys Date: 2020-10-22 Impact factor: 4.071
Authors: Lena S Becker; Klaus Stahl; Timo C Meine; Christian von Falck; Bernhard C Meyer; Cornelia L A Dewald; Nina Rittgerodt; Markus Busch; Sascha David; Frank Wacker; Jan B Hinrichs Journal: Abdom Radiol (NY) Date: 2020-10
Authors: Timo C Meine; Sabine K Maschke; Martha M Kirstein; Elmar Jaeckel; Becker S Lena; Thomas Werncke; Cornelia L A Dewald; Frank K Wacker; Bernhard C Meyer; Jan B Hinrichs Journal: Medicine (Baltimore) Date: 2021-02-19 Impact factor: 1.817
Authors: Cornelia L A Dewald; Lena S Becker; Sabine K Maschke; Timo C Meine; Bernhard C Meyer; Frank K Wacker; Jan B Hinrichs Journal: Cardiovasc Intervent Radiol Date: 2020-12-16 Impact factor: 2.740