Literature DB >> 2884012

Neuroleptics decrease calcium-activated potassium conductance in hippocampal pyramidal cells.

T G Dinan, V Crunelli, J S Kelly.   

Abstract

Intracellular recordings were made from pyramidal CA1-neurones of the hippocampal slice preparation. Bath application of a wide variety of neuroleptics was found to depress the slow afterhyperpolarization, which is mediated in these neurons by a calcium-dependent potassium conductance occurring following a burst of spikes. The depression of this conductance took place in the presence of calcium spikes of normal amplitude and duration, and except in the case of trifluoperazine, without alteration in resting membrane potential or input resistance.

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Year:  1987        PMID： 2884012     DOI： 10.1016/0006-8993(87)91231-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine.

Authors:  Mieke Nys; Eveline Wijckmans; Ana Farinha; Özge Yoluk; Magnus Andersson; Marijke Brams; Radovan Spurny; Steve Peigneur; Jan Tytgat; Erik Lindahl; Chris Ulens
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

2.  Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptors.

Authors:  J W Mozrzymas; A Barberis; K Michalak; E Cherubini
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

3.  Differential inhibition of a transient K+ current by chlorpromazine and 4-aminopyridine in neurones of the rat dorsal root ganglia.

Authors:  N Ogata; H Tatebayashi
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

4.  Effects of dopamine, D-1 and D-2 dopaminergic agonists on the excitability of hippocampal CA1 pyramidal cells in guinea pig.

Authors:  N Berretta; F Berton; R Bianchi; M Capogna; W Francesconi; M Brunelli
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972
  4 in total

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