Literature DB >> 28839719

A multidisciplinary team model of caring for patients with perianal Crohn's disease incorporating a literature review, topical therapy and personal practice.

Vikki Garrick1, Emily Stenhouse2, Graham Haddock3, Richard K Russell1.   

Abstract

BACKGROUND: Crohn's disease (CD) is characterised by periods of relapse and remission. Over time the disease leads almost inevitably to the complications of stricturing, penetration and fistulisation. Perianal CD involves areas of chronic abscess formation, ulceration, skin tags or fistula formation. This can be a particularly challenging and complex problem to manage, and a range of potential treatment modalities exist.
METHODS: This review covers the management of perianal CD and provides recommendations for practice for the multidisciplinary team (MDT), including the use of wound management products and relevant clinical images.
RESULTS: Current practice focuses predominantly on the use of antibiotic therapy, immunosuppression, immunomodulation and surgery. These therapies are used individually or in combination. The majority of evidence suggests that a combination of medical and surgical management produces the best disease outcomes. However, this treatment regime can be debilitating for the patient and compliance can be difficult. Published work on the use of topical therapy in the management of perianal CD focuses specifically on topical drug therapy; it does not, however, address the basic guiding principles of chronic wound management-in particular, optimal moisture control and the management of bacterial burden on the wound surface. Honey and silver-containing wound management products act as topical antimicrobial agents and therefore address these principles.
CONCLUSIONS: Perianal CD is the archetypal condition that exemplifies the need for an MDT approach in caring for patients with inflammatory bowel disease. A combination of treatment modalities that includes topical wound management is likely to produce the best patient outcomes.

Entities:  

Keywords:  Crohn'S Disease

Year:  2012        PMID: 28839719      PMCID: PMC5369793          DOI: 10.1136/flgastro-2012-100160

Source DB:  PubMed          Journal:  Frontline Gastroenterol        ISSN: 2041-4137


  46 in total

1.  Infliximab for the treatment of fistulas in patients with Crohn's disease.

Authors:  D H Present; P Rutgeerts; S Targan; S B Hanauer; L Mayer; R A van Hogezand; D K Podolsky; B E Sands; T Braakman; K L DeWoody; T F Schaible; S J van Deventer
Journal:  N Engl J Med       Date:  1999-05-06       Impact factor: 91.245

2.  Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.

Authors:  G D WINTER
Journal:  Nature       Date:  1962-01-20       Impact factor: 49.962

Review 3.  Perianal Crohn's disease.

Authors:  B Singh; N J McC Mortensen; D P Jewell; B George
Journal:  Br J Surg       Date:  2004-07       Impact factor: 6.939

Review 4.  Review article: treatment of perianal fistulizing Crohn's disease.

Authors:  P Rutgeerts
Journal:  Aliment Pharmacol Ther       Date:  2004-10       Impact factor: 8.171

Review 5.  The evidence supporting the use of honey as a wound dressing.

Authors:  P C Molan
Journal:  Int J Low Extrem Wounds       Date:  2006-03       Impact factor: 2.057

6.  Infliximab in the surgical management of complex fistulating anal Crohn's disease.

Authors:  C Talbot; P M Sagar; M J Johnston; P J Finan; D Burke
Journal:  Colorectal Dis       Date:  2005-03       Impact factor: 3.788

7.  Fistulating anal Crohn's disease: results of combined surgical and infliximab treatment.

Authors:  Syed A Hyder; Simon P L Travis; Derek P Jewell; Neil J McC Mortensen; Bruce D George
Journal:  Dis Colon Rectum       Date:  2006-12       Impact factor: 4.585

8.  Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease.

Authors:  Edward E Stringer; Thomas J Nicholson; David Armstrong
Journal:  Dis Colon Rectum       Date:  2005-05       Impact factor: 4.585

Review 9.  Water for wound cleansing.

Authors:  R Fernandez; R Griffiths; C Ussia
Journal:  Cochrane Database Syst Rev       Date:  2002

10.  Infliximab maintenance therapy for fistulizing Crohn's disease.

Authors:  Bruce E Sands; Frank H Anderson; Charles N Bernstein; William Y Chey; Brian G Feagan; Richard N Fedorak; Michael A Kamm; Joshua R Korzenik; Bret A Lashner; Jane E Onken; Daniel Rachmilewitz; Paul Rutgeerts; Gary Wild; Douglas C Wolf; Paul A Marsters; Suzanne B Travers; Marion A Blank; Sander J van Deventer
Journal:  N Engl J Med       Date:  2004-02-26       Impact factor: 91.245

View more
  2 in total

Review 1.  British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.

Authors:  Christopher Andrew Lamb; Nicholas A Kennedy; Tim Raine; Philip Anthony Hendy; Philip J Smith; Jimmy K Limdi; Bu'Hussain Hayee; Miranda C E Lomer; Gareth C Parkes; Christian Selinger; Kevin J Barrett; R Justin Davies; Cathy Bennett; Stuart Gittens; Malcolm G Dunlop; Omar Faiz; Aileen Fraser; Vikki Garrick; Paul D Johnston; Miles Parkes; Jeremy Sanderson; Helen Terry; Daniel R Gaya; Tariq H Iqbal; Stuart A Taylor; Melissa Smith; Matthew Brookes; Richard Hansen; A Barney Hawthorne
Journal:  Gut       Date:  2019-09-27       Impact factor: 23.059

Review 2.  Management of Crohn's disease.

Authors:  Jochen Kammermeier; Mary-Anne Morris; Vikki Garrick; Mark Furman; Astor Rodrigues; Richard K Russell
Journal:  Arch Dis Child       Date:  2015-11-09       Impact factor: 4.920

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.