Emil K S Espe1, Jan Magnus Aronsen2, Morten Eriksen2, Ole M Sejersted2, Lili Zhang2, Ivar Sjaastad2. 1. From the Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Norway (E.K.S.E., J.M.A., O.M.S., L.Z., I.S.); Bjørknes College, Oslo, Norway (J.M.A.); and Respinor AS, Oslo, Norway (M.E.). ekespe@medisin.uio.no. 2. From the Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Norway (E.K.S.E., J.M.A., O.M.S., L.Z., I.S.); Bjørknes College, Oslo, Norway (J.M.A.); and Respinor AS, Oslo, Norway (M.E.).
Abstract
BACKGROUND: Detailed understanding of regional function after myocardial infarction (MI) is currently incomplete. We aimed at investigating regional myocardial strain and work in post-MI rats with and without heart failure. METHODS AND RESULTS: Six weeks after induction of MI, 62 male Wistar-Hannover rats with a range of infarct sizes, plus 14 sham-operated rats, were examined by cine and phase-contrast magnetic resonance imaging. After magnetic resonance imaging, the rats were catheterized, and left ventricular pressures were recorded. Regional strain and work were calculated from the magnetic resonance imaging and pressure data. On the basis of end-diastolic left ventricular pressure, 34 MI rats were classified as nonfailing (MINF) and 28 MI rats as failing (MICHF). In the region remote to the infarct, the MINF rats exhibited preserved strain and increased work compared with sham, whereas MICHF had reduced longitudinal strain and no increase in work in this region. In the noninfarcted region adjacent to the infarct, MICHF demonstrated substantially reduced work because of high levels of negative work. CONCLUSIONS: We have demonstrated a distinct difference in regional work between nonfailing and failing hearts after MI and offer novel insight into the relation between regional function and presence of congestion. Work analysis provided significant added value over strain analysis alone.
BACKGROUND: Detailed understanding of regional function after myocardial infarction (MI) is currently incomplete. We aimed at investigating regional myocardial strain and work in post-MI rats with and without heart failure. METHODS AND RESULTS: Six weeks after induction of MI, 62 male Wistar-Hannover rats with a range of infarct sizes, plus 14 sham-operated rats, were examined by cine and phase-contrast magnetic resonance imaging. After magnetic resonance imaging, the rats were catheterized, and left ventricular pressures were recorded. Regional strain and work were calculated from the magnetic resonance imaging and pressure data. On the basis of end-diastolic left ventricular pressure, 34 MI rats were classified as nonfailing (MINF) and 28 MI rats as failing (MICHF). In the region remote to the infarct, the MINF rats exhibited preserved strain and increased work compared with sham, whereas MICHF had reduced longitudinal strain and no increase in work in this region. In the noninfarcted region adjacent to the infarct, MICHF demonstrated substantially reduced work because of high levels of negative work. CONCLUSIONS: We have demonstrated a distinct difference in regional work between nonfailing and failing hearts after MI and offer novel insight into the relation between regional function and presence of congestion. Work analysis provided significant added value over strain analysis alone.
Authors: Hanjay Wang; Andrew Wisneski; Annabel M Imbrie-Moore; Michael J Paulsen; Zhongjie Wang; Yue Xuan; Hector Lopez Hernandez; Camille E Hironaka; Haley J Lucian; Hye Sook Shin; Shreya Anilkumar; Akshara D Thakore; Justin M Farry; Anahita Eskandari; Kiah M Williams; Frederick Grady; Matthew A Wu; Jinsuh Jung; Lyndsay M Stapleton; Amanda N Steele; Yuanjia Zhu; Y Joseph Woo Journal: J Mech Behav Biomed Mater Date: 2022-01-04
Authors: Gary McGinley; Bård A Bendiksen; Lili Zhang; Jan Magnus Aronsen; Einar Sjaastad Nordén; Ivar Sjaastad; Emil K S Espe Journal: PLoS One Date: 2019-07-05 Impact factor: 3.240
Authors: Marina Sokolova; Ivar Sjaastad; Mieke C Louwe; Katrine Alfsnes; Jan Magnus Aronsen; Lili Zhang; Solveig B Haugstad; Bård Andre Bendiksen; Jonas Øgaard; Marte Bliksøen; Egil Lien; Rolf K Berge; Pål Aukrust; Trine Ranheim; Arne Yndestad Journal: Front Immunol Date: 2019-07-16 Impact factor: 7.561