Literature DB >> 28837410

New insights into artemisinin regulation.

Zongyou Lv1,2, Lei Zhang2, Kexuan Tang1.   

Abstract

Artemisinin is a sesquiterpene lactone coming from the traditional Chinese herb Artemisia annua L. Artemisinin combination therapies (ACTs) are the main recommended treatment of malaria. Transcription factors regulation of artemisinin belong to different families including AP2/ERF, bHLH, MYB and WRKY. Plant hormones jasmonic acid (JA), abscisic acid (ABA), salicylic acid (SA) and gibberellins (GA) have been described as positively affecting artemisinin biosynthesis in A. annua. Transporter and miRNA open up new possibilities for the biosynthesis of high value artemisinin. We review recently major developments regarding regulator which play a center role in artemisinin biosynthesis, and provide suggestion for further studies.

Entities:  

Keywords:  Artemisia annua L; Artemisinin; hormones; miRNA; transcription factors; transporter

Mesh：

Substances：

Year:  2017        PMID： 28837410      PMCID： PMC5647956          DOI： 10.1080/15592324.2017.1366398

Source DB:  PubMed          Journal:  Plant Signal Behav        ISSN： 1559-2316


  28 in total

1.  TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua.

Authors:  Hexin Tan; Ling Xiao; Shouhong Gao; Qing Li; Junfeng Chen; Ying Xiao; Qian Ji; Ruibing Chen; Wansheng Chen; Lei Zhang
Journal:  Mol Plant       Date:  2015-04-11       Impact factor: 13.164

Review 2.  ABC transporters involved in the transport of plant secondary metabolites.

Authors:  Kazufumi Yazaki
Journal:  FEBS Lett       Date:  2005-12-12       Impact factor: 4.124

Review 3.  A genetic regulatory network in the development of trichomes and root hairs.

Authors:  Tetsuya Ishida; Tetsuya Kurata; Kiyotaka Okada; Takuji Wada
Journal:  Annu Rev Plant Biol       Date:  2008       Impact factor: 26.379

4.  A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2.

Authors:  F L Menke; A Champion; J W Kijne; J Memelink
Journal:  EMBO J       Date:  1999-08-16       Impact factor: 11.598

5.  Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion.

Authors:  Hongzhen Wang; Junli Han; Selvaraju Kanagarajan; Anneli Lundgren; Peter E Brodelius
Journal:  Plant Mol Biol       Date:  2012-11-19       Impact factor: 4.076

6.  A basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua.

Authors:  Fangyuan Zhang; Xueqing Fu; Zongyou Lv; Xu Lu; Qian Shen; Ling Zhang; Mengmeng Zhu; Guofeng Wang; Xiaofen Sun; Zhihua Liao; Kexuan Tang
Journal:  Mol Plant       Date:  2014-12-15       Impact factor: 13.164

7.  Progressive regulation of sesquiterpene biosynthesis in Arabidopsis and Patchouli (Pogostemon cablin) by the miR156-targeted SPL transcription factors.

Authors:  Zong-Xia Yu; Ling-Jian Wang; Bo Zhao; Chun-Min Shan; Yu-Hua Zhang; Dong-Fang Chen; Xiao-Ya Chen
Journal:  Mol Plant       Date:  2014-12-11       Impact factor: 13.164

8.  Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua.

Authors:  Yunpeng Ji; Jingwei Xiao; Yalin Shen; Dongming Ma; Zhenqiu Li; Gaobin Pu; Xing Li; Lili Huang; Benye Liu; Hechun Ye; Hong Wang
Journal:  Plant Cell Physiol       Date:  2014-06-26       Impact factor: 4.927

9.  Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants.

Authors:  Junli Han; Hongzhen Wang; Anneli Lundgren; Peter E Brodelius
Journal:  Phytochemistry       Date:  2014-03-11       Impact factor: 4.072

10.  Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L.

Authors:  Linda Olofsson; Alexander Engström; Anneli Lundgren; Peter E Brodelius
Journal:  BMC Plant Biol       Date:  2011-03-09       Impact factor: 4.215
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  8 in total

1.  Comparative Transcriptomics and Proteomics of Atractylodes lancea in Response to Endophytic Fungus Gilmaniella sp. AL12 Reveals Regulation in Plant Metabolism.

Authors:  Jie Yuan; Wei Zhang; Kai Sun; Meng-Jun Tang; Piao-Xue Chen; Xia Li; Chuan-Chao Dai
Journal:  Front Microbiol       Date:  2019-05-28       Impact factor: 5.640

2.  Molecular identification and expression of sesquiterpene pathway genes responsible for patchoulol biosynthesis and regulation in Pogostemon cablin.

Authors:  Yun Tang; Liting Zhong; Xiaobing Wang; Hai Zheng; Likai Chen
Journal:  Bot Stud       Date:  2019-07-02       Impact factor: 2.787

Review 3.  Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand.

Authors:  Karim Farmanpour-Kalalagh; Arman Beyraghdar Kashkooli; Alireza Babaei; Ali Rezaei; Alexander R van der Krol
Journal:  Front Plant Sci       Date:  2022-02-07       Impact factor: 5.753

4.  Both Two CtACO3 Transcripts Promoting the Accumulation of the Flavonoid Profiles in Overexpressed Transgenic Safflower.

Authors:  Beixuan He; Yanjie Zhang; Lunuan Wang; Dandan Guo; Xinlei Jia; Jianhui Wu; Shuyi Qi; Hong Wu; Yue Gao; Meili Guo
Journal:  Front Plant Sci       Date:  2022-04-06       Impact factor: 5.753

Review 5.  Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches.

Authors:  Kaiser Iqbal Wani; Sadaf Choudhary; Andleeb Zehra; M Naeem; Pamela Weathers; Tariq Aftab
Journal:  Planta       Date:  2021-07-15       Impact factor: 4.116

6.  Genetic Architecture of Capitate Glandular Trichome Density in Florets of Domesticated Sunflower (Helianthus annuus L.).

Authors:  Qing-Ming Gao; Nolan C Kane; Brent S Hulke; Stephan Reinert; Cloe S Pogoda; Silas Tittes; Jarrad R Prasifka
Journal:  Front Plant Sci       Date:  2018-01-09       Impact factor: 5.753

Review 7.  Biotechnological approaches for artemisinin production in Artemisia.

Authors:  Waqas Khan Kayani; Bushra Hafeez Kiani; Erum Dilshad; Bushra Mirza
Journal:  World J Microbiol Biotechnol       Date:  2018-03-27       Impact factor: 3.312

8.  Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model.

Authors:  Jian Li; Bin Wang; Yingying Luo; Yajie Bian; Ruipei Wang
Journal:  Allergy Asthma Clin Immunol       Date:  2018-06-11       Impact factor: 3.406
  8 in total

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