Literature DB >> 28837346

Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici.

Yanjing Zheng1,2, Ke Ma1,3, Haining Lyu1, Ying Huang4, Hongwei Liu1, Ling Liu1, Yongsheng Che5, Xingzhong Liu1, Huixi Zou2, Wen-Bing Yin1,3.   

Abstract

By deleting the COP9 signalosome subunit PfcsnE from Pestalotiopsis fici, seven compounds that were newly produced by the mutant could be characterized, including five new structures, pestaloficins A-E (1 and 3-6). Pestaloficin A (1) represents a new type of dimeric cyclohexanone derivative linked through an unprecedented pentacyclic spiral ring.

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Year:  2017        PMID: 28837346     DOI: 10.1021/acs.orglett.7b02346

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  6 in total

Review 1.  Deep learning approaches for natural product discovery from plant endophytic microbiomes.

Authors:  Shiva Abdollahi Aghdam; Amanda May Vivian Brown
Journal:  Environ Microbiome       Date:  2021-03-18

Review 2.  Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts.

Authors:  Rosa Sagita; Wim J Quax; Kristina Haslinger
Journal:  Front Bioeng Biotechnol       Date:  2021-03-15

Review 3.  Deep learning approaches for natural product discovery from plant endophytic microbiomes.

Authors:  Shiva Abdollahi Aghdam; Amanda May Vivian Brown
Journal:  Environ Microbiome       Date:  2021-03-18

4.  Combination Strategy of Genetic Dereplication and Manipulation of Epigenetic Regulators Reveals a Novel Compound from Plant Endophytic Fungus.

Authors:  Lu Yang; Guangwei Wu; Fanyue Meng; Huomiao Ran; Wenbing Yin; Wei Li; Xiaoqing Liu
Journal:  Int J Mol Sci       Date:  2022-03-28       Impact factor: 5.923

5.  Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids.

Authors:  Jian Bai; Rong Mu; Man Dou; Daojiang Yan; Bingyu Liu; Qian Wei; Jun Wan; Yi Tang; Youcai Hu
Journal:  Acta Pharm Sin B       Date:  2018-02-21       Impact factor: 11.413

6.  Discovery of New Secondary Metabolites by Epigenetic Regulation and NMR Comparison from the Plant Endophytic Fungus Monosporascus eutypoides.

Authors:  Zhe Guo; Zhong-Mei Zou
Journal:  Molecules       Date:  2020-09-12       Impact factor: 4.411

  6 in total

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