Hadar Hallström1, G Rutger Persson2,3, Susann Lindgren4, Stefan Renvert2,5,6. 1. Department of Periodontology, School of Dentistry, Malmö University, Malmö, Sweden. 2. Department of Oral Health Sciences, School of Health and Society, Kristianstad University, Kristianstad, Sweden. 3. Departments of Periodontics, and Oral Medicine, School of Dentistry, University of Washington, Seattle, WA, USA. 4. Maxillofacial Unit, Halland's Hospital, Halmstad, Sweden. 5. School of Dental Science, Trinity College, Dublin, Ireland. 6. Blekinge Institute of Technology, Karlskrona, Sweden.
Abstract
AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics. MATERIALS AND METHODS: Peri-implantitis was surgically treated with or without Zithromax® in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol and intent-to-treat analyses were performed. RESULTS: The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups was 1.7 mm (SD ± 1.1, 95% CI: 1.1, 2.3, p < .001) and 1.6 mm (SD ± 1.5, 95% CI: 0.8, 2,4, p < .001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level and microbial load. Successful treatment (per protocol: PPD ≤ 5 mm, no BOP, no suppuration and no bone loss ≥0.5 mm) at 12 months in test and control groups was 7/15 (46.7%) and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment. CONCLUSIONS: Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide 1-year clinical benefits in comparison with those only receiving open flap debridement.
RCT Entities:
AIMS: To investigate clinical, radiographic and microbiological outcome over 12 months following open flap debridement of peri-implantitis with or without antibiotics. MATERIALS AND METHODS:Peri-implantitis was surgically treated with or without Zithromax® in 19 control and 20 test individuals. Probing pocket depth (PPD), gingival inflammation (BOP), intra-oral radiographs and microbial samples were studied. Per protocol and intent-to-treat analyses were performed. RESULTS: The mean difference (reduction) in PPD values between baseline and month 12 in the test and control groups was 1.7 mm (SD ± 1.1, 95% CI: 1.1, 2.3, p < .001) and 1.6 mm (SD ± 1.5, 95% CI: 0.8, 2,4, p < .001), respectively. Data analysis failed to show study group differences for BOP, PPD, radiographic bone level and microbial load. Successful treatment (per protocol: PPD ≤ 5 mm, no BOP, no suppuration and no bone loss ≥0.5 mm) at 12 months in test and control groups was 7/15 (46.7%) and 4/16 (25.0%). Bacterial load reduction was similar in study groups with a temporary reduction following treatment. CONCLUSIONS: Surgical treatment of peri-implantitis with adjunctive systemic azithromycin did not provide 1-year clinical benefits in comparison with those only receiving open flap debridement.
Authors: Manuel Toledano-Osorio; Cristina Vallecillo; Raquel Toledano; Fátima S Aguilera; María T Osorio; Esther Muñoz-Soto; Franklin García-Godoy; Marta Vallecillo-Rivas Journal: Int J Environ Res Public Health Date: 2022-05-26 Impact factor: 4.614