Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Enhanced survival of ischemic skin flap by combined treatment with bone marrow-derived stem cells and low-level light irradiation.

Literature DB >> 28836013

Enhanced survival of ischemic skin flap by combined treatment with bone marrow-derived stem cells and low-level light irradiation.

Jeong Hwan Moon^1,2,3, Yun-Hee Rhee², Jin-Chul Ahn^2,4, Bongkyun Kim², Sang Joon Lee^1,2, Phil-Sang Chung^5,6,7.

Abstract

The aim of this study is to examine the enhanced survival effect of ischemic skin flap by combined treatment with bone marrow-derived stem cells (BMSCs) and low-level light irradiation (LLLI). The neovasculogenic effect of BMSCs induced by LLLI was detected using a wound healing and tube formation assay. ICR mice were divided into four groups: control group, LLLI group, BMSCs group, and combine-treated group. The percentage of skin flap necrosis area was calculated on the seventh post-operative day. Specimens were harvested for histologic analyses. LLLI promoted BMSC migration and tube formation. The flap survival rate of combined treated group was significantly higher than that of the control group. Histologic results demonstrated a significant increase in neovascularization in the combined treatment group. This study demonstrates that combination treatment of BMSCs and LLLI could enhance the survival of ischemic skin flap in a mouse model.

Entities: Disease Species

Keywords: Bone marrow-derived stem cell; Ischemia; Low-level light; Neovascularization; Skin flap

Mesh：

Substances：
Biomarkers

Year: 2017 PMID： 28836013 DOI： 10.1007/s10103-017-2312-9

Source DB: PubMed Journal: Lasers Med Sci ISSN： 0268-8921 Impact factor: 3.161

28 in total

Review 1. Endothelial progenitor cells: the promise of vascular stem cells for plastic surgery.

Authors: Oren M Tepper; Robert D Galiano; Christoph Kalka; Geoffrey C Gurtner
Journal: Plast Reconstr Surg Date: 2003-02 Impact factor: 4.730

Review 2. Endothelial cell migration during angiogenesis.

Authors: Laurent Lamalice; Fabrice Le Boeuf; Jacques Huot
Journal: Circ Res Date: 2007-03-30 Impact factor: 17.367

3. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract.

Authors: Irina Arnaoutova; Hynda K Kleinman
Journal: Nat Protoc Date: 2010-03-11 Impact factor: 13.491

Review 4. Mechanisms of angiogenesis.

Authors: W Risau
Journal: Nature Date: 1997-04-17 Impact factor: 49.962

5. Dynamics of early stem cell recruitment in skin flaps subjected to ischemia reperfusion injury.

Authors: Ya Hui Tang; Lindsey A Pennington; Jessica W Scordino; Jonathan Steven Alexander; Timothy Lian
Journal: Pathophysiology Date: 2016-07-26

6. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.

Authors: D Lyden; K Hattori; S Dias; C Costa; P Blaikie; L Butros; A Chadburn; B Heissig; W Marks; L Witte; Y Wu; D Hicklin; Z Zhu; N R Hackett; R G Crystal; M A Moore; K A Hajjar; K Manova; R Benezra; S Rafii
Journal: Nat Med Date: 2001-11 Impact factor: 53.440

7. Low-power helium: neon laser irradiation enhances production of vascular endothelial growth factor and promotes growth of endothelial cells in vitro.

Authors: N Kipshidze; V Nikolaychik; M H Keelan; L R Shankar; A Khanna; R Kornowski; M Leon; J Moses
Journal: Lasers Surg Med Date: 2001 Impact factor: 4.025

8. Bone marrow cell implantation improves flap viability after ischemia-reperfusion injury.

Authors: Shigeru Ichioka; Satoshi Kudo; Masahiro Shibata; Joji Ando; Naomi Sekiya; Takashi Nakatsuka
Journal: Ann Plast Surg Date: 2004-04 Impact factor: 1.539

9. The effect of adipose-derived stem cells on ischemia-reperfusion injury: immunohistochemical and ultrastructural evaluation.

Authors: A Cagri Uysal; Hiroshi Mizuno; Morikuni Tobita; Rei Ogawa; Hiko Hyakusoku
Journal: Plast Reconstr Surg Date: 2009-09 Impact factor: 4.730

10. Bone marrow-derived mesenchymal stromal cells improve vascular regeneration and reduce leukocyte-endothelium activation in critical ischemic murine skin in a dose-dependent manner.

Authors: Riccardo Schweizer; Pranitha Kamat; Dennis Schweizer; Cyrill Dennler; Shengye Zhang; Jonas T Schnider; Souzan Salemi; Pietro Giovanoli; Daniel Eberli; Volker Enzmann; Dominique Erni; Jan A Plock
Journal: Cytotherapy Date: 2014-06-24 Impact factor: 5.414

5 in total

1. Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway.

Authors: Yan Shi; Shang Wang; Weiwei Zhang; Yihan Zhu; Zhiqiang Fan; Yuesheng Huang; Furong Li; Ronghua Yang
Journal: Stem Cell Res Ther Date: 2022-07-15 Impact factor: 8.079