Literature DB >> 28835520

Microglia-mediated synaptic elimination in neuronal development and disease.

Brendan S Whitelaw1.   

Abstract

It has recently become clear that microglia, the immune cells of the central nervous system, are far more active in the healthy brain than previously thought. Microglia facilitate many stages of brain development by shaping neuronal connectivity via synaptic elimination. Dysfunction of these same processes likely underlies a wide range of neurological and neurodevelopmental disorders.

Entities:  

Keywords:  ATP; C1q; CX3CR1; P2Y12; complement; development; microglia; synaptic plasticity; synaptic pruning

Mesh：

Year:  2017        PMID： 28835520      PMCID： PMC5866459          DOI： 10.1152/jn.00021.2017

Source DB:  PubMed          Journal:  J Neurophysiol        ISSN： 0022-3077            Impact factor:   2.714


  25 in total

1.  How monocular deprivation shifts ocular dominance in visual cortex of young mice.

Authors:  Mikhail Y Frenkel; Mark F Bear
Journal:  Neuron       Date:  2004-12-16       Impact factor: 17.173

2.  ATP mediates rapid microglial response to local brain injury in vivo.

Authors:  Dimitrios Davalos; Jaime Grutzendler; Guang Yang; Jiyun V Kim; Yi Zuo; Steffen Jung; Dan R Littman; Michael L Dustin; Wen-Biao Gan
Journal:  Nat Neurosci       Date:  2005-05-15       Impact factor: 24.884

3.  Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment.

Authors:  R D Terry; E Masliah; D P Salmon; N Butters; R DeTeresa; R Hill; L A Hansen; R Katzman
Journal:  Ann Neurol       Date:  1991-10       Impact factor: 10.422

Review 4.  Physiology of microglia.

Authors:  Helmut Kettenmann; Uwe-Karsten Hanisch; Mami Noda; Alexei Verkhratsky
Journal:  Physiol Rev       Date:  2011-04       Impact factor: 37.312

5.  Synaptic pruning by microglia is necessary for normal brain development.

Authors:  Rosa C Paolicelli; Giulia Bolasco; Francesca Pagani; Laura Maggi; Maria Scianni; Patrizia Panzanelli; Maurizio Giustetto; Tiago Alves Ferreira; Eva Guiducci; Laura Dumas; Davide Ragozzino; Cornelius T Gross
Journal:  Science       Date:  2011-07-21       Impact factor: 47.728

6.  Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice.

Authors:  Qiaoqiao Shi; Saba Chowdhury; Rong Ma; Kevin X Le; Soyon Hong; Barbara J Caldarone; Beth Stevens; Cynthia A Lemere
Journal:  Sci Transl Med       Date:  2017-05-31       Impact factor: 17.956

7.  Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus.

Authors:  Ukpong B Eyo; Jiyun Peng; Przemyslaw Swiatkowski; Aparna Mukherjee; Ashley Bispo; Long-Jun Wu
Journal:  J Neurosci       Date:  2014-08-06       Impact factor: 6.167

8.  Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects.

Authors:  H-J Kim; M-H Cho; W H Shim; J K Kim; E-Y Jeon; D-H Kim; S-Y Yoon
Journal:  Mol Psychiatry       Date:  2016-07-12       Impact factor: 15.992

Review 9.  Bidirectional synaptic mechanisms of ocular dominance plasticity in visual cortex.

Authors:  Gordon B Smith; Arnold J Heynen; Mark F Bear
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2009-02-12       Impact factor: 6.237

10.  Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.

Authors:  G O Sipe; R L Lowery; M-È Tremblay; E A Kelly; C E Lamantia; A K Majewska
Journal:  Nat Commun       Date:  2016-03-07       Impact factor: 14.919
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  10 in total

Review 1.  Features of the EEG Pattern of Sleep Spindles and Its Diagnostic Significance in Ontogeny.

Authors:  E B Ukhinov; I M Madaeva; O N Berdina; L V Rychkova; L I Kolesnikova; S I Kolesnikov
Journal:  Bull Exp Biol Med       Date:  2022-09-05       Impact factor: 0.737

2.  Development and sensory experience dependent regulation of microglia in barrel cortex.

Authors:  John Kalambogias; Chia-Chien Chen; Safraz Khan; Titus Son; Racheli Wercberger; Carolyn Headlam; Cindy Lin; Joshua C Brumberg
Journal:  J Comp Neurol       Date:  2019-10-18       Impact factor: 3.215

3.  ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex.

Authors:  Nicole Piera Palomba; Katiuscia Martinello; Germana Cocozza; Sara Casciato; Addolorata Mascia; Giancarlo Di Gennaro; Roberta Morace; Vincenzo Esposito; Heike Wulff; Cristina Limatola; Sergio Fucile
Journal:  J Neuroinflammation       Date:  2021-02-15       Impact factor: 8.322

Review 4.  Microglia and Neuroinflammation: What Place for P2RY12?

Authors:  Albert Gómez Morillas; Valérie C Besson; Dominique Lerouet
Journal:  Int J Mol Sci       Date:  2021-02-06       Impact factor: 5.923

5.  Auditory Brainstem Deficits from Early Treatment with a CSF1R Inhibitor Largely Recover with Microglial Repopulation.

Authors:  Giedre Milinkeviciute; Sima M Chokr; Karina S Cramer
Journal:  eNeuro       Date:  2021-03-22

6.  DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84.

Authors:  Wen-Shuang Gao; Yu-Juan Qu; Juan Huai; Hui Wei; Yang Zhang; Shou-Wei Yue
Journal:  Aging (Albany NY)       Date:  2020-12-03       Impact factor: 5.682

Review 7.  PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity.

Authors:  Ben Rombaut; Sofie Kessels; Melissa Schepers; Assia Tiane; Dean Paes; Yevgeniya Solomina; Elisabeth Piccart; Daniel van den Hove; Bert Brône; Jos Prickaerts; Tim Vanmierlo
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

8.  C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.

Authors:  Deepti Lall; Ileana Lorenzini; Thomas A Mota; Shaughn Bell; Thomas E Mahan; Jason D Ulrich; Hayk Davtyan; Jessica E Rexach; A K M Ghulam Muhammad; Oksana Shelest; Jesse Landeros; Michael Vazquez; Junwon Kim; Layla Ghaffari; Jacqueline Gire O'Rourke; Daniel H Geschwind; Mathew Blurton-Jones; David M Holtzman; Rita Sattler; Robert H Baloh
Journal:  Neuron       Date:  2021-06-15       Impact factor: 18.688

9.  CX3CR1 mutation alters synaptic and astrocytic protein expression, topographic gradients, and response latencies in the auditory brainstem.

Authors:  Giedre Milinkeviciute; Sima M Chokr; Emily M Castro; Karina S Cramer
Journal:  J Comp Neurol       Date:  2021-04-14       Impact factor: 3.028

10.  Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition.

Authors:  Dongliang Li; Mingming Chen; Tao Meng; Jianchun Fei
Journal:  J Neuroinflammation       Date:  2020-04-07       Impact factor: 8.322
  10 in total

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