Literature DB >> 288351

Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.

W Hauser, N Weger.   

Abstract

Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.

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Year:  1979        PMID： 288351     DOI： 10.1007/978-3-642-67265-1_44

Source DB:  PubMed          Journal:  Arch Toxicol Suppl        ISSN： 0171-9750


  4 in total

1.  Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation.

Authors:  H P van Helden; J de Lange; R W Busker; B P Melchers
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

2.  Reactivators of organophosphate-inhibited cholinesterase. Phenylhydroxymethyl and cyclohexylhydroxymethyl substituted bis-pyridinium monooximes.

Authors:  V Deljac; M Maksimović; L Radović; D Rakin; V Markov; I Bregovec; Z Binenfeld
Journal:  Arch Toxicol       Date:  1982-03       Impact factor: 5.153

3.  Therapy of organophosphate poisoning: the marmoset as a model for man.

Authors:  H P van Helden; H J van der Wiel; O L Wolthuis
Journal:  Br J Pharmacol       Date:  1983-03       Impact factor: 8.739

4.  Effect of the bispyridinium compounds HGG12, HGG42, and obidoxime on synaptic transmission and NAD(P)H-fluorescence in the superior cervical ganglion of the rat in vitro.

Authors:  D M Kirsch; N Weger
Journal:  Arch Toxicol       Date:  1981-06       Impact factor: 5.153
  4 in total

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