Changqing Zhao1,2, Mingjuan Jin2,3, Richard Hieu Le2, Michael Huan Le4, Vincent Lingzhi Chen2, Michelle Jin2, Grace Lai-Hung Wong5, Vincent Wai-Sun Wong5, Young-Suk Lim6, Wan-Long Chuang7, Ming-Lung Yu7, Mindie H Nguyen2. 1. Department of Cirrhosis, Institute of Liver Disease, Shuguang Hospital, Shanghai University of T. C. M., Shanghai, China. 2. Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA. 3. Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou, China. 4. University of California, Santa Cruz, CA, USA. 5. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. 6. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 7. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Abstract
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) surveillance is associated with improved outcomes and long-term survival. Our goal is to evaluate adherence rates to HCC surveillance. METHODS: We performed a systematic search of the PubMed and Scopus databases and abstract search of relevant studies from recent major liver meetings. All searches and data extraction were performed independently by two authors. Analysis was via random-effects models and multivariate meta-regression. RESULTS: A total of 22 studies (n = 19 511) met inclusion criteria (original non-interventional studies with defined cirrhosis or chronic hepatitis B or chronic hepatitis C with advanced fibrosis populations, and surveillance tests and intervals). Overall adherence rate was 52% (95% CI 38%-66%). Adherence was significantly higher in cirrhotic patients compared to chronic hepatitis B and other high-risk patients, in European compared to North American studies, in less than 12-month compared to yearly surveillance intervals, and in prospective compared to retrospective studies (71%, 95% CI 64%-78% vs 39%, 95% CI 26%-51%, P < .001). The between-study heterogeneity of all above analyses was significant (P < .001). Only the study design (retrospective vs prospective cohort) had statistical significance in a multivariate meta-regression model (P < .05) and could account for some of the differences above. CONCLUSIONS: Overall adherence rate to HCC surveillance was suboptimal at 52% with no significant differences by liver disease aetiology or study location in multivariate meta-regression analysis. Further research and educational efforts are needed to improve the current rate of HCC surveillance.
BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) surveillance is associated with improved outcomes and long-term survival. Our goal is to evaluate adherence rates to HCC surveillance. METHODS: We performed a systematic search of the PubMed and Scopus databases and abstract search of relevant studies from recent major liver meetings. All searches and data extraction were performed independently by two authors. Analysis was via random-effects models and multivariate meta-regression. RESULTS: A total of 22 studies (n = 19 511) met inclusion criteria (original non-interventional studies with defined cirrhosis or chronic hepatitis B or chronic hepatitis C with advanced fibrosis populations, and surveillance tests and intervals). Overall adherence rate was 52% (95% CI 38%-66%). Adherence was significantly higher in cirrhotic patients compared to chronic hepatitis B and other high-risk patients, in European compared to North American studies, in less than 12-month compared to yearly surveillance intervals, and in prospective compared to retrospective studies (71%, 95% CI 64%-78% vs 39%, 95% CI 26%-51%, P < .001). The between-study heterogeneity of all above analyses was significant (P < .001). Only the study design (retrospective vs prospective cohort) had statistical significance in a multivariate meta-regression model (P < .05) and could account for some of the differences above. CONCLUSIONS: Overall adherence rate to HCC surveillance was suboptimal at 52% with no significant differences by liver disease aetiology or study location in multivariate meta-regression analysis. Further research and educational efforts are needed to improve the current rate of HCC surveillance.
Authors: Vincent L Chen; Ming-Lun Yeh; Ju Dong Yang; Jennifer Leong; Daniel Q Huang; Hidenori Toyoda; Yao-Li Chen; Jennifer Guy; Mayumi Maeda; Pei-Chien Tsai; Chung-Feng Huang; Satoshi Yasuda; An K Le; Hansen Dang; Nasra H Giama; Hamdi A Ali; Ning Zhang; Xiaozhong Wang; Dae Won Jun; Cheng-Hao Tseng; Yao-Chun Hsu; Jee-Fu Huang; Chia-Yen Dai; Wan-Long Chuang; Qiang Zhu; Yock Young Dan; Myron Schwartz; Lewis R Roberts; Ming-Lung Yu; Mindie H Nguyen Journal: Hepatol Commun Date: 2020-09-24