Hoda A Moneib1, Sahar S Youssef1, Dalia G Aly2, Mohamed A Rizk3, Yomna I Abdelhakeem4. 1. Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt. 2. Department of Dermatology and Venereology, National Research Centre, Giza, Egypt. 3. Department of Vascular Surgery, Ain Shams University, Cairo, Egypt. 4. Al Haud Almarsoud Hospital, Cairo, Egypt.
Abstract
BACKGROUND:Chronic venous leg ulcers drastically reduce the quality of life of affected patients. There is heightened interest in autologous platelet-rich plasma (PRP) as one of the promising therapies for leg ulcers. AIM: Our aim was to compare the clinical efficacy of PRP in the management of chronic venous leg ulcers vs conventional treatment. PATIENTS/ METHODS: In total, 40 patients with chronic venous leg ulcers were included in the study. Twenty patients were treated withautologous PRP weekly for 6 weeks (Group A), and 20 patients were treated with conventional treatment (compression and dressing) for 6 weeks (Group B). Treatment results were calculated by percentage of improvement in area of the ulcer. RESULTS: Compared to conventional therapy, a highly significant improvement in the ulcer size was observed post-PRP therapy (P-value = .0001). The mean change in the area of the ulcer post-PRP and conventional therapy was 4.92 ± 11.94 cm and 0.13 ± 0.27 cm, respectively, while the mean percentage improvement in the area of the ulcer post-PRP and conventional therapy was 67.6% ± 36.6% and 13.67% ± 28.06%, respectively. Subjective improvement in pain associated with the ulcer was noted by all patients. CONCLUSIONS:Platelet-rich plasma is a safe nonsurgical procedure for treating chronic venous leg ulcers. Additional studies with larger sample size and longer follow-up periods are required to confirm or refute our findings.
RCT Entities:
BACKGROUND:Chronic venous leg ulcers drastically reduce the quality of life of affected patients. There is heightened interest in autologous platelet-rich plasma (PRP) as one of the promising therapies for leg ulcers. AIM: Our aim was to compare the clinical efficacy of PRP in the management of chronic venous leg ulcers vs conventional treatment. PATIENTS/ METHODS: In total, 40 patients with chronic venous leg ulcers were included in the study. Twenty patients were treated with autologous PRP weekly for 6 weeks (Group A), and 20 patients were treated with conventional treatment (compression and dressing) for 6 weeks (Group B). Treatment results were calculated by percentage of improvement in area of the ulcer. RESULTS: Compared to conventional therapy, a highly significant improvement in the ulcer size was observed post-PRP therapy (P-value = .0001). The mean change in the area of the ulcer post-PRP and conventional therapy was 4.92 ± 11.94 cm and 0.13 ± 0.27 cm, respectively, while the mean percentage improvement in the area of the ulcer post-PRP and conventional therapy was 67.6% ± 36.6% and 13.67% ± 28.06%, respectively. Subjective improvement in pain associated with the ulcer was noted by all patients. CONCLUSIONS: Platelet-rich plasma is a safe nonsurgical procedure for treating chronic venous leg ulcers. Additional studies with larger sample size and longer follow-up periods are required to confirm or refute our findings.
Authors: Andreas Bayer; Bernard Wijaya; Lena Möbus; Franziska Rademacher; Meno Rodewald; Mersedeh Tohidnezhad; Thomas Pufe; Daniel Drücke; Regine Gläser; Jürgen Harder Journal: Int J Mol Sci Date: 2020-06-20 Impact factor: 5.923
Authors: Deborah Chicharro; Jose M Carrillo; Mónica Rubio; Ramón Cugat; Belén Cuervo; Silvia Guil; Jerónimo Forteza; Victoria Moreno; Jose M Vilar; Joaquín Sopena Journal: BMC Vet Res Date: 2018-09-21 Impact factor: 2.741
Authors: Min He; Xuewen Guo; Tao Li; Xiaoyan Jiang; Yan Chen; Yi Yuan; Bing Chen; Gangyi Yang; Yahan Fan; Ziwen Liang; David G Armstrong; Wuquan Deng Journal: Cell Transplant Date: 2020 Jan-Dec Impact factor: 4.064