Literature DB >> 28833669

A Tumor-Specific Cascade Amplification Drug Release Nanoparticle for Overcoming Multidrug Resistance in Cancers.

Mingzhou Ye1,2, Yuxin Han1, Jianbin Tang1, Ying Piao1, Xiangrui Liu1, Zhuxian Zhou1, Jianqing Gao2, Jianghong Rao3, Youqing Shen1.   

Abstract

A cascade amplification release nanoparticle (CARN) is constructed by the coencapsulation of β-lapachone and a reactive-oxygen-species (ROS)-responsive doxorubicin (DOX) prodrug, BDOX, in polymeric nanoparticles. Releasing β-lapachone first from the CARNs selectively increases the ROS level in cancer cells via NAD(P)H:quinone oxidoreductase-1 (NQO1) catalysis, which induces the cascade amplification release of DOX and overcomes multidrug resistance (MDR) in cancer cells, producing a remarkably improved therapeutic efficacy against MDR tumors with minimal side effects.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  anticancer prodrug; cascade amplification drug release; drug delivery; multidrug resistance; β-lapachone

Mesh：

Substances：

Year:  2017        PMID： 28833669     DOI： 10.1002/adma.201702342

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  31 in total

1.  Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials.

Authors:  Roy Weinstain; Tomáš Slanina; Dnyaneshwar Kand; Petr Klán
Journal:  Chem Rev       Date:  2020-10-30       Impact factor: 60.622

2.  pH-Responsive Hyaluronic Acid Nanoparticles for Enhanced Triple Negative Breast Cancer Therapy.

Authors:  Xiangle Zeng; Hairong Wang; Yawen Zhang; Xue Xu; Xinyi Yuan; Jianchun Li
Journal:  Int J Nanomedicine       Date:  2022-03-25

3.  Ultrasound Combined with Core Cross-Linked Nanosystem for Enhancing Penetration of Doxorubicin Prodrug/Beta-Lapachone into Tumors.

Authors:  Qianyan Li; Wei Hou; Meixuan Li; Hemin Ye; Huanan Li; Zhibiao Wang
Journal:  Int J Nanomedicine       Date:  2020-07-07

Review 4.  Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.

Authors:  Yuzhe Sun; Edward Davis
Journal:  Nanomaterials (Basel)       Date:  2021-03-16       Impact factor: 5.076

5.  A pH-Responsive Charge-Reversal Drug Delivery System with Tumor-Specific Drug Release and ROS Generation for Cancer Therapy.

Authors:  Chen Xu; Rijin Song; Pei Lu; Jianchun Chen; Yongqiang Zhou; Gang Shen; Minjun Jiang; Wei Zhang
Journal:  Int J Nanomedicine       Date:  2020-01-08

6.  Cascade Drug-Release Strategy for Enhanced Anticancer Therapy.

Authors:  Xu Zhang; Sheng Wang; Guohui Cheng; Peng Yu; Jin Chang; Xiaoyuan Chen
Journal:  Matter       Date:  2021-01-06

Review 7.  Reactive Oxygen Species-Based Nanomaterials for Cancer Therapy.

Authors:  Yingbo Li; Jie Yang; Xilin Sun
Journal:  Front Chem       Date:  2021-04-22       Impact factor: 5.221

8.  ROS-responsive dimeric prodrug-based nanomedicine targeted therapy for gastric cancer.

Authors:  Jiachi Ma; Yuzhong Chen; Wanqing Liang; Lei Li; Jun Du; Chengwu Pan; Chensong Zhang
Journal:  Drug Deliv       Date:  2021-12       Impact factor: 6.419

9.  Nanostructured lipid carriers co-delivering lapachone and doxorubicin for overcoming multidrug resistance in breast cancer therapy.

Authors:  Xin Li; Xiaoqian Jia; Hu Niu
Journal:  Int J Nanomedicine       Date:  2018-07-12

10.  Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors.

Authors:  Yao Tang; Yuejia Ji; Chenglin Yi; Di Cheng; Bin Wang; Yun Fu; Yufang Xu; Xuhong Qian; Yahya E Choonara; Viness Pillay; Weiping Zhu; Yunen Liu; Zhihong Nie
Journal:  Theranostics       Date:  2020-07-09       Impact factor: 11.556
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