Angelina Maric1, Eszter Montvai1, Esther Werth1, Matthias Storz1, Janina Leemann1, Sebastian Weissengruber2, Christian C Ruff2, Reto Huber3,4, Rositsa Poryazova1, Christian R Baumann1. 1. Department of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. 2. Laboratory for Social and Neural Systems Research (SNS-Lab), Department of Economics, University of Zurich, Zurich, Switzerland. 3. Child Development Center and Pediatric Sleep Disorders Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland. 4. Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Abstract
OBJECTIVES: Chronic sleep restriction is highly prevalent in modern society and is, in its clinical form, insufficient sleep syndrome, one of the most prevalent diagnoses in clinical sleep laboratories, with substantial negative impact on health and community burden. It reflects every-day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as, for example, risky decision making. METHODS: We assessed financial risk-taking behavior after 7 consecutive nights of sleep restriction and after 1 night of acute sleep deprivation compared to a regular sleep condition in a within-subject design. We further investigated potential underlying mechanisms of sleep-loss-induced changes in behavior by high-density electroencephalography recordings during restricted sleep. RESULTS: We show that chronic sleep restriction increases risk-seeking, whereas this was not observed after acute sleep deprivation. This increase was subjectively not noticed and was related to locally lower values of slow-wave energy during preceding sleep, an electrophysiological marker of sleep intensity and restoration, in electrodes over the right prefrontal cortex. INTERPRETATION: This study provides, for the first time, evidence that insufficient sleep restoration over circumscribed cortical areas leads to aberrant behavior. In chronically sleep restricted subjects, low slow-wave sleep intensity over the right prefrontal cortex-which has been shown to be linked to risk behavior-may lead to increased and subjectively unnoticed risk-seeking. Ann Neurol 2017;82:409-418.
OBJECTIVES: Chronic sleep restriction is highly prevalent in modern society and is, in its clinical form, insufficient sleep syndrome, one of the most prevalent diagnoses in clinical sleep laboratories, with substantial negative impact on health and community burden. It reflects every-day sleep loss better than acute sleep deprivation, but its effects and particularly the underlying mechanisms remain largely unknown for a variety of critical cognitive domains, as, for example, risky decision making. METHODS: We assessed financial risk-taking behavior after 7 consecutive nights of sleep restriction and after 1 night of acute sleep deprivation compared to a regular sleep condition in a within-subject design. We further investigated potential underlying mechanisms of sleep-loss-induced changes in behavior by high-density electroencephalography recordings during restricted sleep. RESULTS: We show that chronic sleep restriction increases risk-seeking, whereas this was not observed after acute sleep deprivation. This increase was subjectively not noticed and was related to locally lower values of slow-wave energy during preceding sleep, an electrophysiological marker of sleep intensity and restoration, in electrodes over the right prefrontal cortex. INTERPRETATION: This study provides, for the first time, evidence that insufficient sleep restoration over circumscribed cortical areas leads to aberrant behavior. In chronically sleep restricted subjects, low slow-wave sleep intensity over the right prefrontal cortex-which has been shown to be linked to risk behavior-may lead to increased and subjectively unnoticed risk-seeking. Ann Neurol 2017;82:409-418.
Authors: Gaetan Petit; Ana Maria Cebolla; Sara Fattinger; Mathieu Petieau; Leopold Summerer; Guy Cheron; Reto Huber Journal: NPJ Microgravity Date: 2019-05-02 Impact factor: 4.415
Authors: Cathalijn H C Leenaars; Stevie Van der Mierden; Ruud N J M A Joosten; Marnix A Van der Weide; Mischa Schirris; Maurice Dematteis; Franck L B Meijboom; Matthijs G P Feenstra; André Bleich Journal: Clocks Sleep Date: 2021-01-20
Authors: Jeryl Y L Lim; Johanna Boardman; Jeff Dyche; Clare Anderson; David L Dickinson; Sean P A Drummond Journal: Sleep Date: 2022-09-08 Impact factor: 6.313