Literature DB >> 2883293

Detrimental effect of propylene glycol on natural killer cell and neutrophil function.

D W Denning, A D Webster.   

Abstract

Propylene glycol (PG) in a concentration of 0.5-1.0% inhibits natural cytotoxicity and neutrophil chemiluminescence. This is the first reported effect of PG on defence mechanisms in man. PG is frequently used as a vehicle in high concentrations by the pharmaceutical industry and it would be wise to consider its potential immunosuppressive effects in the evaluation of drug formulations.

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Year:  1987        PMID： 2883293     DOI： 10.1111/j.2042-7158.1987.tb06258.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  3 in total

1.  Clear castable polyurethane elastomer for fabrication of microfluidic devices.

Authors:  Karel Domansky; Daniel C Leslie; James McKinney; Jacob P Fraser; Josiah D Sliz; Tiama Hamkins-Indik; Geraldine A Hamilton; Anthony Bahinski; Donald E Ingber
Journal:  Lab Chip       Date:  2013-10-07       Impact factor: 6.799

Review 2.  Immunosuppressive aspects of analgesics and sedatives used in mechanically ventilated patients: an underappreciated risk factor for the development of ventilator-associated pneumonia in critically ill patients.

Authors:  Michael A Smith; Maho Hibino; Bonnie A Falcione; Katherine M Eichinger; Ravi Patel; Kerry M Empey
Journal:  Ann Pharmacother       Date:  2013-11-04       Impact factor: 3.154

3.  Hematological, Biochemical, Histopathological and ¹H-NMR Metabolomics Application in Acute Toxicity Evaluation of Clinacanthus nutans Water Leaf Extract.

Authors:  Leng Wei Khoo; Audrey Siew Foong Kow; M Maulidiani; Ming Tatt Lee; Chin Ping Tan; Khozirah Shaari; Chau Ling Tham; Faridah Abas
Journal:  Molecules       Date:  2018-08-29       Impact factor: 4.411
  3 in total

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