Ntobeko A B Ntusi1. 1. aDivision of Cardiology, Department of Medicine, University of Cape Town and Groote Schuur Hospital bThe Cape Universities Body Imaging Centre cThe Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Abstract
PURPOSE OF REVIEW: The purpose of this article is to review the literature on HIV and myocarditis and HIV-associated heart failure. RECENT FINDINGS: Currently, 17 million people are receiving antiretroviral therapy (ART) globally. There is a decrease in mortality from HIV in the last decade with increased survival in those receiving ART. HIV-associated cardiac failure is on the increase, with more cases of diastolic dysfunction reported in the ART era. The pathophysiology of HIV-associated myocarditis is multifactorial. Cardiovascular magnetic resonance (CMR), through tissue characterization, demonstrates increased native T1 values which reflect both increased myocardial inflammation and fibrosis in HIV infection. SUMMARY: HIV-associated myocarditis is common and may be an important cause of HIV-associated cardiac failure. CMR is an important imaging modality for the study of myocardial inflammation.
PURPOSE OF REVIEW: The purpose of this article is to review the literature on HIV and myocarditis and HIV-associated heart failure. RECENT FINDINGS: Currently, 17 million people are receiving antiretroviral therapy (ART) globally. There is a decrease in mortality from HIV in the last decade with increased survival in those receiving ART. HIV-associated cardiac failure is on the increase, with more cases of diastolic dysfunction reported in the ART era. The pathophysiology of HIV-associated myocarditis is multifactorial. Cardiovascular magnetic resonance (CMR), through tissue characterization, demonstrates increased native T1 values which reflect both increased myocardial inflammation and fibrosis in HIV infection. SUMMARY: HIV-associated myocarditis is common and may be an important cause of HIV-associated cardiac failure. CMR is an important imaging modality for the study of myocardial inflammation.
Authors: Kyle A Batton; Christopher O Austin; Katelyn A Bruno; Charles D Burger; Brian P Shapiro; DeLisa Fairweather Journal: Biol Sex Differ Date: 2018-04-18 Impact factor: 5.027
Authors: Daniel Brayson; Andrea Frustaci; Romina Verardo; Cristina Chimenti; Matteo Antonio Russo; Robert Hayward; Sadia Ahmad; Gema Vizcay-Barrena; Andrea Protti; Peter S Zammit; Cristobal G dos Remedios; Elisabeth Ehler; Ajay M Shah; Catherine M Shanahan Journal: JCI Insight Date: 2019-11-14