Pål O Borgen1, Olav Reikeras2. 1. Department of Orthopedics, Martina Hansens Hospital, Norway. 2. Department of Orthopedics, Oslo University Hospital, Rikshospitalet, Norway.
Abstract
OBJECTIVE: To study the time course and correlation of prothrombin fragment (F1 + 2) in plasma and urine during THA. METHOD: F1 + 2 concentrations were recorded at four time-points during THA. RESULTS: F1 + 2 increased during surgery. In contrast to urine, plasma F1 + 2 was temporarily reduced the first postoperative day. At day six, plasma F1 + 2 was significantly elevated indicating on-going thrombin activation, while urine F1 + 2 was normalized. CONCLUSION: The response in coagulation to operative trauma can be recorded with F1 + 2 both in plasma and urine. We were not able to demonstrate any correlation of F1 + 2 in plasma and urine later in the postoperative period.
OBJECTIVE: To study the time course and correlation of prothrombin fragment (F1 + 2) in plasma and urine during THA. METHOD: F1 + 2 concentrations were recorded at four time-points during THA. RESULTS: F1 + 2 increased during surgery. In contrast to urine, plasma F1 + 2 was temporarily reduced the first postoperative day. At day six, plasma F1 + 2 was significantly elevated indicating on-going thrombin activation, while urine F1 + 2 was normalized. CONCLUSION: The response in coagulation to operative trauma can be recorded with F1 + 2 both in plasma and urine. We were not able to demonstrate any correlation of F1 + 2 in plasma and urine later in the postoperative period.
Entities:
Keywords:
Biomarkers; Prophylaxis; Thrombosis; Total hip arthroplasty
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