PURPOSE: Wilms tumor (WT) and neuroblastoma (NB) are the most common pediatric abdominal malignant neoplasms of the kidney and adrenal gland. Differentiating them from each other is essential since their treatments are different. Here, we aimed to show the diffusion characteristics of WT and NB for differentiation. METHODS: Diffusion-weighted imaging (DWI) of 17 histopathologically diagnosed lesions (10 NB and 7 WT in 8 female and 9 male patients) was evaluated retrospectively. The apparent diffusion coefficient (ADC) value for each tumor was calculated using region-of-interest (ROI) measurements by two observers. The mean ADC values were compared, and receiver operating characteristics (ROC) curve analysis was performed. Intraclass correlation was evaluated for the reliability of ADC measurement. RESULTS: The mean ADC values measured by two observers were 0.787±0.09 ×10-3 mm2/s and 0.768±0.08 ×10-3 mm2/s for WT, and 0.524±0.16 ×10-3 mm2/s and 0.529±0.16 ×10-3 mm2/s for NB, respectively (P = 0.006 and P = 0.011). Intraclass correlation coefficient was 0.955. Utilizing ROC curve analysis, a cutoff ADC value of ≤0.645 ×10-3 mm2/s was obtained to differentiate NB from WT. CONCLUSION: ADC values of NBs were significantly lower than WT with a perfect interobserver agreement. We suggest that DWI may have a role in differentiating the two tumors.
PURPOSE:Wilms tumor (WT) and neuroblastoma (NB) are the most common pediatric abdominal malignant neoplasms of the kidney and adrenal gland. Differentiating them from each other is essential since their treatments are different. Here, we aimed to show the diffusion characteristics of WT and NB for differentiation. METHODS: Diffusion-weighted imaging (DWI) of 17 histopathologically diagnosed lesions (10 NB and 7 WT in 8 female and 9 male patients) was evaluated retrospectively. The apparent diffusion coefficient (ADC) value for each tumor was calculated using region-of-interest (ROI) measurements by two observers. The mean ADC values were compared, and receiver operating characteristics (ROC) curve analysis was performed. Intraclass correlation was evaluated for the reliability of ADC measurement. RESULTS: The mean ADC values measured by two observers were 0.787±0.09 ×10-3 mm2/s and 0.768±0.08 ×10-3 mm2/s for WT, and 0.524±0.16 ×10-3 mm2/s and 0.529±0.16 ×10-3 mm2/s for NB, respectively (P = 0.006 and P = 0.011). Intraclass correlation coefficient was 0.955. Utilizing ROC curve analysis, a cutoff ADC value of ≤0.645 ×10-3 mm2/s was obtained to differentiate NB from WT. CONCLUSION: ADC values of NBs were significantly lower than WT with a perfect interobserver agreement. We suggest that DWI may have a role in differentiating the two tumors.
Authors: Hervé J Brisse; M Beth McCarville; Claudio Granata; K Barbara Krug; Sandra L Wootton-Gorges; Kimio Kanegawa; Francesco Giammarile; Matthias Schmidt; Barry L Shulkin; Katherine K Matthay; Valerie J Lewington; Sabine Sarnacki; Barbara Hero; Michio Kaneko; Wendy B London; Andrew D J Pearson; Susan L Cohn; Tom Monclair Journal: Radiology Date: 2011-05-17 Impact factor: 11.105
Authors: Justine N van der Beek; Tom A Watson; Rutger A J Nievelstein; Hervé J Brisse; Carlo Morosi; Henrique M Lederman; Ana Coma; Maria M Gavra; Kristina Vult von Steyern; Karoly Lakatos; Luc Breysem; Edit Varga; Hubert Ducou Le Pointe; Maarten H Lequin; Jürgen F Schäfer; Hans-Joachim Mentzel; Andreas M Hötker; Giuseppina Calareso; Sophie Swinson; Martin Kyncl; Claudio Granata; Michael Aertsen; Pier Luigi Di Paolo; Ronald R de Krijger; Norbert Graf; Øystein E Olsen; Jens-Peter Schenk; Marry M van den Heuvel-Eibrink; Annemieke S Littooij Journal: J Magn Reson Imaging Date: 2021-08-06 Impact factor: 5.119
Authors: Anita Adriaantje Harteveld; Annemieke Simone Littooij; Max Maria van Noesel; Marijn van Stralen; Clemens Bos Journal: MAGMA Date: 2021-08-03 Impact factor: 2.310