Literature DB >> 28830838

Members of FOX family could be drug targets of cancers.

Jinhua Wang1, Wan Li2, Ying Zhao2, Weiqi Fu2, Xiangjin Zheng2, Xiaocong Pang2, Guanhua Du3.   

Abstract

FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance, FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer; Drug resistance; Drug target; FOX family; FOXM1; Stem cell

Mesh：

Substances：

Year:  2017        PMID： 28830838     DOI： 10.1016/j.pharmthera.2017.08.003

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  17 in total

1.  c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression.

Authors:  Wen-Die Wang; Yue Shang; Chen Wang; Jun Ni; Ai-Min Wang; Gao-Jie Li; Ling Su; Shu-Zhen Chen
Journal:  Acta Pharmacol Sin       Date:  2022-04-14       Impact factor: 6.150

2.  Retracted Article: FOXC1 silencing promotes A549 cell apoptosis through inhibiting the PI3K/AKT/hedgehog/Gli2 signaling pathway.

Authors:  Pei Wang; Hongbing Ma; Yong Li; Dong Chen; Xiaohui Li; Xiang Gao
Journal:  RSC Adv       Date:  2018-10-02       Impact factor: 4.036

3.  TGFβ-induced FOXS1 controls epithelial-mesenchymal transition and predicts a poor prognosis in liver cancer.

Authors:  Kevin Bévant; Matthis Desoteux; Gaëlle Angenard; Raphaël Pineau; Stefano Caruso; Corentin Louis; Panagiotis Papoutsoglou; Laurent Sulpice; David Gilot; Jessica Zucman-Rossi; Cédric Coulouarn
Journal:  Hepatol Commun       Date:  2021-11-26

Review 4.  FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles.

Authors:  Zhi Yang; Shuai Jiang; Yicheng Cheng; Tian Li; Wei Hu; Zhiqiang Ma; Fulin Chen; Yang Yang
Journal:  Ther Adv Med Oncol       Date:  2017-11-23       Impact factor: 8.168

5.  Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.

Authors:  Nenggang Zhang; Debananda Pati
Journal:  J Cancer Sci Ther       Date:  2018-03-22

6.  FOXC2 is a prognostic biomarker and contributes to the growth and invasion of human hepatocellular carcinoma.

Authors:  Jinzhang Chen; Xiaoxiang Rong; Xinhui Liu; Dayong Zheng; Xiaodong Rong; Fengsheng Chen; Peng Zhao; Feiye Liu; Jian Ruan
Journal:  Cancer Cell Int       Date:  2020-05-26       Impact factor: 5.722

7.  Forkhead box K1 regulates the malignant behavior of gastric cancer by inhibiting autophagy.

Authors:  Yixuan Wang; Wensheng Qiu; Ning Liu; Libin Sun; Zhao Liu; Shasha Wang; Peng Wang; Shihai Liu; Jing Lv
Journal:  Ann Transl Med       Date:  2020-02

8.  FGFR1/FOXM1 pathway: a key regulator of glioblastoma stem cells radioresistance and a prognosis biomarker.

Authors:  Elizabeth Cohen-Jonathan Moyal; Christine Toulas; Valérie Gouazé-Andersson; Marie-Julie Ghérardi; Anthony Lemarié; Julia Gilhodes; Vincent Lubrano; Florent Arnauduc
Journal:  Oncotarget       Date:  2018-08-03

9.  FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC.

Authors:  Sisi Cao; Zhuo Wang; Xiujuan Gao; Wenjuan He; Yue Cai; Hui Chen; Rong Xu
Journal:  J Exp Clin Cancer Res       Date:  2018-09-06

10.  Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis.

Authors:  Chaojie Liang; Jingyang Zhao; Hua Ge; Guangming Li; Jixiang Wu
Journal:  Onco Targets Ther       Date:  2018-06-19       Impact factor: 4.147
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