| Literature DB >> 28830306 |
Isil Ezgi Eryilmaz1, Gulsah Cecener1, Sevda Erer2, Unal Egeli1, Berrin Tunca1, Mehmet Zarifoglu1, Bulent Elibol3, Ayse Bora Tokcaer4, Esen Saka3, Meltem Demirkiran5, Cenk Akbostanci6, Okan Dogu7, Beril Colakoglu8, Gulay Kenangil9, Hakan Kaleagasi7.
Abstract
Background and aim The effect of epigenetic modifications in the genes related to Parkinson's disease (PD) is still unclear. In the present study, we investigated methylation status of SNCA and PARK2 genes in patients with early-onset Parkinson's disease (EOPD). Materials and methods The promoter region methylation status of SNCA and PARK2 genes was evaluated by methylation specific-PCR (MSP) in 91 patients with EOPD and 52 healthy individuals. Results The methylation of SNCA and PARK2 promoter regions were significantly lower in EOPD patients compared to the control group (P = 0.013 and P = 0.03, respectively). We also found that the methylation status of the SNCA might be associated with positive family history of PD (P = 0.042). Conclusion Although it should be supported by further analysis, based on the results of the present study, the methylation status of SNCA and PARK2 genes might contribute to EOPD pathogenesis.Entities:
Keywords: Early-onset Parkinson’s disease; PARK2; SNCA; epigenetic; methylation
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Year: 2017 PMID： 28830306 DOI： 10.1080/01616412.2017.1368141
Source DB: PubMed Journal: Neurol Res ISSN： 0161-6412 Impact factor: 2.448