S Li1, H Li, R Wang, J-P Zhang. 1. Department of Endocrinology, Beijing University of Chinese Medicine, Third Affiliated Hospital, Beijing, China. zi7j52@163.com.
Abstract
OBJECTIVE: The objective of the present study was to observe the effect of sitagliptin on obese patients with insulin treatment-induced diabetes mellitus. PATIENTS AND METHODS: A total of 120 obese patients with insulin treatment-induced diabetes mellitus were consecutively selected and divided into the control group (n=35), observation group 1 (n=40), and observation group 2 (n=45). The control group received different types or doses of insulin, observation group 1 received insulin combined with metformin, and observation group 2 received insulin combined with sitagliptin. The therapeutic effects were compared at the 6-month follow-up visit. RESULTS:Body mass index (BMI) was lower in observation group 1 and observation group 2, and higher in the control group compared with before treatment; the occurrence of hypoglycemia in observation group 2 was lower than in the other two groups, and the differences were statistically significant (p<0.05). After treatment, the fasting insulin (FINS) and homeostatic model assessment insulin-resistance (HOMA-IR) in observation group 2 were significantly lower than in the other two groups (p<0.05). Adiponectin levels were increased and leptin and visfatin levels were decreased in observation group 2 after treatment, and the differences were statistically significant (p<0.05). The levels of fasting blood glucose, hemoglobinA1c, total cholesterol, triglyceride, and low-density lipoprotein in the three groups were not significantly different (p>0.05). CONCLUSIONS:Sitagliptin can reduce BMI and the occurrence of hypoglycemia in obese patients with insulin treatment-induced diabetes mellitus, and the effect may be related to decreased HOMA-IR, decreased leptin and visfatin levels, and increased adiponectin levels.
RCT Entities:
OBJECTIVE: The objective of the present study was to observe the effect of sitagliptin on obesepatients with insulin treatment-induced diabetes mellitus. PATIENTS AND METHODS: A total of 120 obesepatients with insulin treatment-induced diabetes mellitus were consecutively selected and divided into the control group (n=35), observation group 1 (n=40), and observation group 2 (n=45). The control group received different types or doses of insulin, observation group 1 received insulin combined with metformin, and observation group 2 received insulin combined with sitagliptin. The therapeutic effects were compared at the 6-month follow-up visit. RESULTS: Body mass index (BMI) was lower in observation group 1 and observation group 2, and higher in the control group compared with before treatment; the occurrence of hypoglycemia in observation group 2 was lower than in the other two groups, and the differences were statistically significant (p<0.05). After treatment, the fasting insulin (FINS) and homeostatic model assessment insulin-resistance (HOMA-IR) in observation group 2 were significantly lower than in the other two groups (p<0.05). Adiponectin levels were increased and leptin and visfatin levels were decreased in observation group 2 after treatment, and the differences were statistically significant (p<0.05). The levels of fasting blood glucose, hemoglobin A1c, total cholesterol, triglyceride, and low-density lipoprotein in the three groups were not significantly different (p>0.05). CONCLUSIONS:Sitagliptin can reduce BMI and the occurrence of hypoglycemia in obesepatients with insulin treatment-induced diabetes mellitus, and the effect may be related to decreased HOMA-IR, decreased leptin and visfatin levels, and increased adiponectin levels.
Authors: L D'Elia; A Giaquinto; F P Cappuccio; R Iacone; O Russo; P Strazzullo; F Galletti Journal: J Endocrinol Invest Date: 2019-11-05 Impact factor: 4.256