| Literature DB >> 28829141 |
Zhi-Jun Zhang1,2, Yin Nian3, Qin-Feng Zhu1,2, Xiao-Nian Li1, Jia Su1, Xing-De Wu1, Jian Yang3, Qin-Shi Zhao1.
Abstract
Lycoplanine A (1), a Lycopodium alkaloid with a 6/9/5 tricyclic ring skeleton fused with the γ-lactone ring and featuring an unusual 1-oxa-6-azaspiro[4.4]nonane moiety and an unprecedented 3-azabicyclo[6.3.1]dodecane unit, was isolated from the club moss Lycopodium complanatum. The structure and absolute configuration of 1 were identified by a combination of NMR spectroscopic analysis and single-crystal X-ray diffraction. Biological studies showed that 1 is a potent Cav3.1 T-type calcium channel (TTCC) inhibitor with an IC50 value of 6.06 μM.Entities:
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Year: 2017 PMID： 28829141 DOI： 10.1021/acs.orglett.7b02293
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005