Literature DB >> 28828674

Isolation of Extracellular Vesicles from Stem Cells.

Zixin Chen1,2, Yongjun Li1,3, Hong Yu4, Yan Shen1, Chengwei Ju1,3, Genshan Ma3, Yutao Liu1, Il-Man Kim1, Neal L Weintraub1, Yaoliang Tang5.   

Abstract

Transplanted induced pluripotent stem cells (IPSC ) and embryonic stem cells (ESC) exhibit enhanced survival in ischemic tissues and promote survival of neighboring cells via paracrine effects. Recent studies indicate that stem cells can secrete extracellular vesicles (EV), which can shuttle noncoding RNA between cells and facilitate intercellular signaling and communication between donor stem cells and recipient tissues. Direct transplantation of IPSC -derived EV (IPSC -EV) is highly effective at promoting survival and preventing apoptosis of cardiomyocytes in a mouse model of acute myocardial ischemia-reperfusion (MI/R). Here, we describe a feasible protocol to purify EV from cultured IPSC .

Entities:  

Keywords:  Extracellular vesicles; Induced pluripotent stem cells

Mesh：

Year:  2017        PMID： 28828674      PMCID： PMC5813491          DOI： 10.1007/978-1-4939-7253-1_32

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  19 in total

1.  Two-step protocol for isolation and culture of cardiospheres.

Authors:  Lijuan Chen; Yaohua Pan; Lan Zhang; Yingjie Wang; Neal Weintraub; Yaoliang Tang
Journal:  Methods Mol Biol       Date:  2013

2.  MiR-92a regulates viability and angiogenesis of endothelial cells under oxidative stress.

Authors:  Lan Zhang; Mi Zhou; Gangjian Qin; Neal L Weintraub; Yaoliang Tang
Journal:  Biochem Biophys Res Commun       Date:  2014-03-17       Impact factor: 3.575

Review 3.  Cross talk between the Notch signaling and noncoding RNA on the fate of stem cells.

Authors:  Yaoliang Tang; Yingjie Wang; Lijuan Chen; Yaohua Pan; Neal Weintraub
Journal:  Prog Mol Biol Transl Sci       Date:  2012       Impact factor: 3.622

4.  Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.

Authors:  Mohsin Khan; Emily Nickoloff; Tatiana Abramova; Jennifer Johnson; Suresh Kumar Verma; Prasanna Krishnamurthy; Alexander Roy Mackie; Erin Vaughan; Venkata Naga Srikanth Garikipati; Cynthia Benedict; Veronica Ramirez; Erin Lambers; Aiko Ito; Erhe Gao; Sol Misener; Timothy Luongo; John Elrod; Gangjian Qin; Steven R Houser; Walter J Koch; Raj Kishore
Journal:  Circ Res       Date:  2015-04-22       Impact factor: 17.367

5.  Enhancing stem cell survival in an ischemic heart by CRISPR-dCas9-based gene regulation.

Authors:  Alexander Pan; Neal L Weintraub; Yaoliang Tang
Journal:  Med Hypotheses       Date:  2014-10-13       Impact factor: 1.538

6.  Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium.

Authors:  Yao Liang Tang; Qiang Zhao; Y Clare Zhang; Leilei Cheng; Mingya Liu; Jianhui Shi; Yin Zeng Yang; Chuizhen Pan; Junbo Ge; M Ian Phillips
Journal:  Regul Pept       Date:  2004-01-15

Review 7.  Cardiac-derived stem cell-based therapy for heart failure: progress and clinical applications.

Authors:  Yaoliang L Tang; Yingjie J Wang; Lijuan J Chen; Yaohua H Pan; Lan Zhang; Neal L Weintraub
Journal:  Exp Biol Med (Maywood)       Date:  2013-03

8.  Application of the zeta potential measurements to explanation of colloidal Cr2O3 stability mechanism in the presence of the ionic polyamino acids.

Authors:  Iwona Ostolska; Małgorzata Wiśniewska
Journal:  Colloid Polym Sci       Date:  2014-06-04       Impact factor: 1.931

9.  Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium.

Authors:  Yingjie Wang; Lan Zhang; Yongjun Li; Lijuan Chen; Xiaolong Wang; Wei Guo; Xue Zhang; Gangjian Qin; Sheng-hu He; Arthur Zimmerman; Yutao Liu; Il-man Kim; Neal L Weintraub; Yaoliang Tang
Journal:  Int J Cardiol       Date:  2015-05-08       Impact factor: 4.164

Review 10.  Crosstalk between Long Noncoding RNAs and MicroRNAs in Health and Disease.

Authors:  Ahmed S Bayoumi; Amer Sayed; Zuzana Broskova; Jian-Peng Teoh; James Wilson; Huabo Su; Yao-Liang Tang; Il-Man Kim
Journal:  Int J Mol Sci       Date:  2016-03-11       Impact factor: 5.923
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  7 in total

1.  Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis.

Authors:  Chengwei Ju; Youngjun Li; Yan Shen; Yutao Liu; Jingwen Cai; Naifeng Liu; Gengshan Ma; Yaoliang Tang
Journal:  J Cardiovasc Transl Res       Date:  2018-10-01       Impact factor: 4.132

2.  Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro.

Authors:  Xiao-Fen Ruan; Yong-Jun Li; Cheng-Wei Ju; Yan Shen; Wei Lei; Can Chen; Yang Li; Hong Yu; Yu-Tao Liu; Il-Man Kim; Xiao-Long Wang; Neal L Weintraub; Yaoliang Tang
Journal:  Acta Pharmacol Sin       Date:  2018-03-15       Impact factor: 6.150

3.  Exosome-Derived Dystrophin from Allograft Myogenic Progenitors Improves Cardiac Function in Duchenne Muscular Dystrophic Mice.

Authors:  Xuan Su; Yue Jin; Yan Shen; Chengwei Ju; Jingwen Cai; Yutao Liu; Il-Man Kim; Yu Wang; Hong Yu; Neal L Weintraub; Meng Jiang; Yaoliang Tang
Journal:  J Cardiovasc Transl Res       Date:  2018-08-28       Impact factor: 4.132

4.  Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium.

Authors:  Chengwei Ju; Yan Shen; Gengshan Ma; Yutao Liu; Jingwen Cai; Il-Man Kim; Neal L Weintraub; Naifeng Liu; Yaoliang Tang
Journal:  J Cardiovasc Transl Res       Date:  2018-09-19       Impact factor: 4.132

Review 5.  The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics.

Authors:  Abhimanyu Thakur; Xiaoshan Ke; Ya-Wen Chen; Pedram Motallebnejad; Kui Zhang; Qizhou Lian; Huanhuan Joyce Chen
Journal:  Protein Cell       Date:  2021-08-10       Impact factor: 15.328

Review 6.  Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies.

Authors:  Ilaria Laurenzana; Daniela Lamorte; Stefania Trino; Luciana De Luca; Concetta Ambrosino; Pietro Zoppoli; Vitalba Ruggieri; Luigi Del Vecchio; Pellegrino Musto; Antonella Caivano; Geppino Falco
Journal:  Stem Cells Int       Date:  2018-05-27       Impact factor: 5.443

7.  Noncoding RNAs and Stem Cell Function and Therapy.

Authors:  Yaoliang Tang; Wei Lei; Yanfang Chen; Xiaolong Wang; Mark W Hamrick; Mi Zhou
Journal:  Stem Cells Int       Date:  2018-06-05       Impact factor: 5.443
  7 in total

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