| Literature DB >> 28826229 |
Elizabeth A Kelvin1, Gavin George2, Eva Mwai3, Eston Nyaga3, Joanne E Mantell4, Matthew L Romo1, Jacob O Odhiambo3, Lila Starbuck1, Kaymarlin Govender2.
Abstract
We conducted a randomized controlled trial among 305 truck drivers from two North Star Alliance roadside wellness clinics in Kenya to see if offering HIV testing choices would increase HIV testing uptake. Participants were randomized to be offered (1) a provider-administered rapid blood (finger-prick) HIV test (i.e., standard of care [SOC]) or (2) a Choice between SOC or a self-administered oral rapid HIV test with provider supervision in the clinic. Participants in the Choice arm who refused HIV testing in the clinic were offered a test kit for home use with phone-based posttest counseling. We compared HIV test uptake using the Mantel Haenszel odds ratio (OR) adjusting for clinic. Those in the Choice arm had higher odds of HIV test uptake than those in the SOC arm (OR = 1.5), but the difference was not statistically significant (p = 0.189). When adding the option to take an HIV test kit for home use, the Choice arm had significantly greater odds of testing uptake (OR = 2.8, p = 0.002). Of those in the Choice arm who tested, 26.9% selected the SOC test, 64.6% chose supervised self-testing in the clinic, and 8.5% took a test kit for home use. Participants varied in the HIV test they selected when given choices. Importantly, when participants who refused HIV testing in the clinic were offered a test kit for home use, an additional 8.5% tested. Offering truck drivers a variety of HIV testing choices may increase HIV testing uptake in this key population.Entities:
Keywords: Diagnostic tests; HIV; HIV testing; Kenya
Mesh:
Year: 2017 PMID: 28826229 PMCID: PMC5901679 DOI: 10.1080/09540121.2017.1360997
Source DB: PubMed Journal: AIDS Care ISSN: 0954-0121
Figure 1.Flow of study participants (Consort Flowchart).
Descriptive statistics for the sample overall and by randomization arm.
| Variable | Total, | SOC Arm, | Choice Arm, | |
|---|---|---|---|---|
| Total | 305 | 155 (50.8%) | 150 (49.2%) | NA |
| Clinic where recruited | 0.787 | |||
| Clinic 1 | 144 (47.2%) | 72 (46.5%) | 72 (48.0%) | |
| Clinic 2 | 161 (52.8%) | 83 (53.5%) | 78 (52.0%) | |
| Age in years | 0.989a | |||
| Mean (SD) | 37.0 (7.9) | 36.9 (8.0) | 37.2 (7.8) | |
| Median (range) | 36.0 (21.0–62.0) | 35.0 (21.0–60.0) | 37.0 (24.0–62.0) | |
| High school graduate | 0.417 | |||
| No | 196 (64.3%) | 103 (66.5%) | 93 (62.0%) | |
| Yes | 109 (35.7%) | 52 (33.5%) | 57 (38.0%) | |
| Mean trucking income per month (Kenyan Shillings) | 0.074 | |||
| 8,000–15,999 KES | 15 (5.2%) | 12 (8.1%) | 3 (2.1%) | |
| 16,000–23,999 KES | 65 (22.6%) | 33 (22.3%) | 32 (22.9%) | |
| 24,000–55,000 KES | 208 (72.2%) | 103 (69.6%) | 105 (75.0%) | |
| Number of years worked as truck driver | 0.650a | |||
| Mean (SD) | 8.7 (7.1) | 9.0 (7.8) | 8.4 (6.3) | |
| Median (range) | 6.7 (1.0–38.9) | 6.7 (1.0–38.9) | 6.7 (1.0–37.0) | |
| Clinic is on usual trucking route | 0.573 | |||
| No | 51 (16.8%) | 24 (15.6%) | 27 (18.0%) | |
| Yes | 253 (83.2%) | 130 (84.4%) | 123 (82.0%) | |
| Number of nights away from home in the past 30 days | 0.495a | |||
| Mean (SD) | 21.6 (5.6) | 21.3 (5.9) | 21.8 (5.3) | |
| Median (range) | 22.5 (0.0–30.0) | 22.0 (0.0–30.0) | 23 (2.0–30.0) | |
| Came to clinic specifically for HIV testing | 0.365 | |||
| No | 173 (56.7%) | 84 (54.2%) | 89 (59.3%) | |
| Yes | 132 (43.3%) | 71 (45.8%) | 61 (40.7%) | |
| Sexually active in the past 6 months | 0.116b | |||
| No | 6 (2.0%) | 1 (0.7%) | 5 (3.4%) | |
| Yes | 295 (98.0%) | 152 (99.3%) | 143 (96.6%) | |
| Married (legal or common law) | 0.999 | |||
| No | 51 (16.9%) | 26 (16.9%) | 25 (16.9%) | |
| Yes | 251 (83.1%) | 128 (83.1%) | 123 (83.1%) | |
| Has other regular partner(s) on the trucking route | 0.619 | |||
| No | 163 (53.4%) | 85 (54.8%) | 78 (52.0%) | |
| Yes | 142 (46.6%) | 70 (45.2%) | 72 (48.0%) | |
| Paid for sex in the past 6 months | 0.789 | |||
| No | 126 (44.1%) | 65 (43.3%) | 61 (44.9%) | |
| Yes | 160 (55.9%) | 85 (56.7%) | 75 (55.1%) | |
| Always used condoms when had sex in the past 6 months (among those who had sex) | 0.358 | |||
| No | 250 (85.9%) | 127 (84.1%) | 123 (87.9%) | |
| Yes | 41 (14.1%) | 24 (15.9%) | 17 (12.1%) | |
| Ever tested for HIV before | 0.259 | |||
| No | 25 (8.2%) | 10 (6.5%) | 15 (10.0%) | |
| Yes | 280 (91.8%) | 145 (93.5%) | 135 (90.0%) | |
| Number of years since last HIV test among those ever tested | 0.934a | |||
| Mean (SD) | 1.1 (1.6) | 1.0 (1.4) | 1.1 (1.9) | |
| Median (range) | 0.5 (0.1–12.0) | 0.5 (0.1–7.4) | 0.5 (0.1–12.0) | |
| Ever self-tested for HIV among those who ever tested | 0.499b | |||
| No | 276 (99.3%) | 142 (98.6%) | 134 (100.0%) | |
| Yes | 2 (0.7%) | 2 (1.4%) | 0 (0.0%) |
aMann-Whitney U test.
bFisher’s exact test.
HIV test uptake overall and by intervention status under intent-to-treat (i.e., by randomization assignment) and per protocol (i.e., by what was actually offered).
| Total, | SOC arm, | Choice arm, | Mantel Haenszel OR (95% CI) adjusting for strata | Mantel Haenszel | |
|---|---|---|---|---|---|
| Total as randomized | 305 (100%) | 155 (50.8%) | 150 (49.2%) | NA | NA |
| Total per protocol | 305 (100%) | 156 (51.1%) | 149 (48.9%) | NA | NA |
| Tested in clinic (intent-to-treat analysis) | |||||
| Yes | 233 (76.4%) | 113 (72.9%) | 120 (80.0%) | 1.5 (0.9–2.7) | 0.189 |
| No | 72 (23.5%) | 42 (27.1%) | 30 (20.0%) | NA | NA |
| Tested in clinic (per protocol analysis)a | |||||
| Yes | 233 (76.4%) | 114 (73.1%) | 119 (79.9%) | 1.5 (0.9–2.7) | 0.196 |
| No | 72 (23.6%) | 42 (26.9%) | 30 (20.1%) | NA | NA |
| Tested either in clinic or took test kit for home use (intent-to-treat analysis) | |||||
| Yes | 244 (80.0%) | 113 (72.9%) | 131 (87.3%) | 2.8 (1.5–5.4) | 0.002 |
| No | 61 (20.0%) | 42 (27.1%) | 19 (12.7%) | ||
| Tested either in clinic or took test kit for home use (per protocol analysis)a | |||||
| Yes | 244 (80.0%) | 114 (73.1%) | 130 (87.2%) | 2.8 (1.5–5.4) | 0.002 |
| No | 61 (20.0%) | 42 (26.9%) | 19 (12.8%) | NA | NA |
aOne participant in the choice arm was only offered the SOC HIV test.
HIV test used and reasons given for the test choice among those offered choices who agreed to test (n = 130).
| Reason for test selected | SOC test, | Supervised self-administered rapid oral test in the clinic, | Self-administered rapid oral HIV test take for home use, |
|---|---|---|---|
| Total | 35 (26.9%) | 84 (64.6%) | 11 (8.5%) |
| Prefer provider to administer/interpret the test | 28 (80.0%) | NA | NA |
| Prefer to administer/interpret the test myself | NA | 13 (15.5%) | 10 (90.9%) |
| Trust the provider can administer the test correctly | 5 (14.3%) | NA | NA |
| Do not trust the provider to administer/interpret the test correctly | NA | 1 (1.2%) | 0 (0.0%) |
| Not confident that I could do the test correctly myself | 6 (17.1%) | NA | NA |
| Feel confident that I can administer the test myself correctly | NA | 21 (25.0%) | 5 (45.5%) |
| Trust the provider to keep the results confidential | 4 (11.4%) | NA | NA |
| Do not trust the provider to keep the results confidential | NA | 1 (1.2%) | 0 (0.0%) |
| Prefer to be the only one who knows my results | NA | 1 (1.2%) | 1 (9.1%) |
| Prefer to have someone with me when testing | 1 (2.9%) | NA | NA |
| Prefer to be alone when testing | NA | 1 (1.2%) | 4 (36.4%) |
| Prefer to be with a partner or loved one when testing | NA | NA | 5 (45.5%) |
| Feel uncomfortable in clinic settings | NA | NA | 1 (9.1%) |
| Prefer a blood test | 21 (60.0%) | NA | NA |
| Prefer an oral test | NA | 13 (15.5%) | 3 (27.3%) |
| Wanted to try the new test/curious about the new test | NA | 75 (89.3%) | 0 (0%) |
| Did not have time to stay at the clinic to test | NA | NA | 3 (27.3%) |
aOnly offered to those in the choice arm who refused both in-clinic HIV testing options.
HIV test results for those who tested by randomization arm.
| SOC Arm, | Choice Arm, | |
|---|---|---|
| Total who tested | 113 (100%) | 131 (100%) |
| HIV-positive | 2 (1.8%) | 0 (0%) |
| HIV-negative | 111 (98.2%) | 131 (100%) |
| Refused to disclose (self-testers only) | NA | 0 (0.0%) |