Tommaso Fedele1, Claudio Schönenberger2, Gabriel Curio3, Carlo Serra2, Niklaus Krayenbühl2, Johannes Sarnthein4. 1. Neurosurgery Department, University Hospital Zurich, Zurich, Switzerland. Electronic address: tommaso.fedele@usz.ch. 2. Neurosurgery Department, University Hospital Zurich, Zurich, Switzerland. 3. Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité, Berlin, Germany. 4. Neurosurgery Department, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Neuroscience Center Zurich, Zurich, Switzerland.
Abstract
OBJECTIVE: The detectability of high frequency oscillations (HFO, >200Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA). METHODS: In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia. RESULTS: In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p<0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p<0.001) for recordings with low impedance (<5kΩ). Average amplitudes were indistinguishable between anesthesia compounds. CONCLUSION: Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance. SIGNIFICANCE: Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings.
OBJECTIVE: The detectability of high frequency oscillations (HFO, >200Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA). METHODS: In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia. RESULTS: In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p<0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p<0.001) for recordings with low impedance (<5kΩ). Average amplitudes were indistinguishable between anesthesia compounds. CONCLUSION: Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance. SIGNIFICANCE: Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings.