Sung Ho Jang1, Hyeok Gyu Kwon. 1. From the Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Gyeongsan, Republic of Korea (SHJ); and Department of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Pusan, Republic of Korea (HGK).
Abstract
OBJECTIVES: The survival rate for hypoxic-ischemic brain injury (HI-BI) is less than 20%. Several brain regions, including the caudate, hippocampus, and hypothalamus, are vulnerable to HI-BI. Hypothalamus is involved in regulation of temperature, sleep-wakefulness cycle, emotional behavior, and memory function. Using diffusion tensor imaging, we examined injury of the hypothalamus in patients with HI-BI. METHODS: Twelve patients with HI-BI and 27 healthy control subjects were recruited. The region of interest was defined for the hypothalamus and the fractional anisotropy and apparent diffusion coefficient were measured. RESULTS: The fractional anisotropy value was significantly lower in the patient group compared with the control group (P < 0.05), whereas the apparent diffusion coefficient value was significantly higher compared with that of the control group (P < 0.05). In the individual analysis, 7 (58.3%) of 12 patients and 14 (58.3%) of 24 hemispheres showed a decrement or increment of more than two SDs in either fractional anisotropy or apparent diffusion coefficient values compared with the control group. CONCLUSIONS: Using diffusion tensor imaging, injury of the hypothalamus was demonstrated in patients with HI-BI. Our methodology and results of this study would be helpful in research on the hypothalamus in patients with HI-BI.
OBJECTIVES: The survival rate for hypoxic-ischemic brain injury (HI-BI) is less than 20%. Several brain regions, including the caudate, hippocampus, and hypothalamus, are vulnerable to HI-BI. Hypothalamus is involved in regulation of temperature, sleep-wakefulness cycle, emotional behavior, and memory function. Using diffusion tensor imaging, we examined injury of the hypothalamus in patients with HI-BI. METHODS: Twelve patients with HI-BI and 27 healthy control subjects were recruited. The region of interest was defined for the hypothalamus and the fractional anisotropy and apparent diffusion coefficient were measured. RESULTS: The fractional anisotropy value was significantly lower in the patient group compared with the control group (P < 0.05), whereas the apparent diffusion coefficient value was significantly higher compared with that of the control group (P < 0.05). In the individual analysis, 7 (58.3%) of 12 patients and 14 (58.3%) of 24 hemispheres showed a decrement or increment of more than two SDs in either fractional anisotropy or apparent diffusion coefficient values compared with the control group. CONCLUSIONS: Using diffusion tensor imaging, injury of the hypothalamus was demonstrated in patients with HI-BI. Our methodology and results of this study would be helpful in research on the hypothalamus in patients with HI-BI.
Authors: Kengo Onda; Eva Catenaccio; Jill Chotiyanonta; Raul Chavez-Valdez; Avner Meoded; Bruno P Soares; Aylin Tekes; Harisa Spahic; Sarah C Miller; Sarah-Jane Parker; Charlamaine Parkinson; Dhananjay M Vaidya; Ernest M Graham; Carl E Stafstrom; Allen D Everett; Frances J Northington; Kenichi Oishi Journal: Front Neurosci Date: 2022-08-02 Impact factor: 5.152