Literature DB >> 2882446

Region-specific loss of glutamate innervation in Alzheimer's disease.

J Hardy, R Cowburn, A Barton, G Reynolds, E Lofdahl, A M O'Carroll, P Wester, B Winblad.   

Abstract

Synaptosomal D-aspartate has been used as a marker for glutamate neurons in control and in postmortem Alzheimer's disease brains. This technique shows a marked (60%) decrease of the glutamate uptake site in cortical and hippocampal regions. There were no significant changes in subcortical regions. We interpret these results as indicating loss of, or damage to, cortical glutamatergic innervation. These losses probably represent the biochemical correlate of pyramidal neuron damage in Alzheimer's disease.

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Year:  1987        PMID： 2882446     DOI： 10.1016/0304-3940(87)90034-6

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  18 in total

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9.  Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer's disease.

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