Chong-Yang Ding1, Hai Li2, Chong Liu2, Xiao Li3. 1. Department of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. 2. Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. 3. Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. E-mail:ilixiao@126.com.
Abstract
OBJECTIVE: To explore the clinical presentation, imaging characteristics of 18F-FDG PET/CT and prognosis of patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL). METHODS: The images and clinical data of 7 patients with pathologically confirmed SPTCL who underwent 18F-FDG PET/CT were retrospectively analyzed. RESULTS: Six patients displayed multiple subcutaneous nodules or deeply seated plaques, most commonly on the extremities and trunk, and one patient showed a single lesion on his face. The ulceration of nodules occurred in 3 cases, and the lesions were painful in 5 cases. Both nodal and extranodal involvements were found in 2 cases, respectively. The SUVmax of cutaneous lesions in extremities and trunk were 3.8(1.1-11.3) and 3.9(1.0-10.1), with out significant difference (Z=-0.248, P>0.05), but significant difference was observed between the SUVmax cutaneous lesions with the CT value>0HU group and that of CT value≤0HU group [7.0(3.0-11.3) vs 1.8(1.0-6.9); Z=-7.523, P<0.01]. The SUVmax of all cutaneous lesions, nodal and extranodal involvement were 3.9(1.0-11.3), 5.2(2.1-13.1) and 6.2(4.0-11.4), respectively, with significant difference(P<0.05). The SUVmax of extranodal involvement was apparently higher than that of cutaneous lesions (P<0.05). However, no significant difference of the SUVmax was observed between nodal and extranodal involvement (P>0.0.5), also between nodal involvement and cutaneous lesions (P>0.05). Among 7 cases, 4 were died of multiple cutaneous lesions, and accompanied by hemophagocytic syndrome (HPS) in 3 cases, with median SUVmax of cutaneous lesions exceeded 3.0 in 3 cases, and nodal and extranodal involvement in 2 cases. CONCLUSION: The clinical manifestation of SPTCL is non-specific. 18F-FDG PET/CT is useful for defining the distribution and extent, finding visceral involvement, judging the malignant degree, predicting the prognosis, and making effective therapeutic plan.
OBJECTIVE: To explore the clinical presentation, imaging characteristics of 18F-FDG PET/CT and prognosis of patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL). METHODS: The images and clinical data of 7 patients with pathologically confirmed SPTCL who underwent 18F-FDG PET/CT were retrospectively analyzed. RESULTS: Six patients displayed multiple subcutaneous nodules or deeply seated plaques, most commonly on the extremities and trunk, and one patient showed a single lesion on his face. The ulceration of nodules occurred in 3 cases, and the lesions were painful in 5 cases. Both nodal and extranodal involvements were found in 2 cases, respectively. The SUVmax of cutaneous lesions in extremities and trunk were 3.8(1.1-11.3) and 3.9(1.0-10.1), with out significant difference (Z=-0.248, P>0.05), but significant difference was observed between the SUVmax cutaneous lesions with the CT value>0HU group and that of CT value≤0HU group [7.0(3.0-11.3) vs 1.8(1.0-6.9); Z=-7.523, P<0.01]. The SUVmax of all cutaneous lesions, nodal and extranodal involvement were 3.9(1.0-11.3), 5.2(2.1-13.1) and 6.2(4.0-11.4), respectively, with significant difference(P<0.05). The SUVmax of extranodal involvement was apparently higher than that of cutaneous lesions (P<0.05). However, no significant difference of the SUVmax was observed between nodal and extranodal involvement (P>0.0.5), also between nodal involvement and cutaneous lesions (P>0.05). Among 7 cases, 4 were died of multiple cutaneous lesions, and accompanied by hemophagocytic syndrome (HPS) in 3 cases, with median SUVmax of cutaneous lesions exceeded 3.0 in 3 cases, and nodal and extranodal involvement in 2 cases. CONCLUSION: The clinical manifestation of SPTCL is non-specific. 18F-FDG PET/CT is useful for defining the distribution and extent, finding visceral involvement, judging the malignant degree, predicting the prognosis, and making effective therapeutic plan.