Pablo M Linares1, Alicia Algaba2, Ana Urzainqui3, Mercedes Guijarro-Rojas4, Rafael González-Tajuelo3, Jesús Garrido5, María Chaparro1, Javier P Gisbert1, Fernando Bermejo2, Iván Guerra2, Víctor Castellano6, María-Encarnación Fernández-Contreras7,8. 1. Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), C/ Diego de León 62, 28006, Madrid, Spain. 2. Department of Gastroenterology, Hospital Universitario de Fuenlabrada, C/ Camino del Molino 2, 28942, Fuenlabrada-Madrid, Spain. 3. Department of Immunology, Hospital Universitario de la Princesa, IIS-IP, C/ Diego de León 62, 28006, Madrid, Spain. 4. Department of Pathology, Hospital Universitario de la Princesa, IIS-IP, C/ Diego de León 62, 28006, Madrid, Spain. 5. Department of Social Psychology and Methodology, School of Psychology, Universidad Autónoma de Madrid (UAM), C/ Ivan Pavlov 6. Ciudad Universitaria de Cantoblanco, 28049, Madrid, Spain. 6. Department of Pathology, Hospital Universitario de Fuenlabrada, C/ Camino del Molino 2, 28942, Fuenlabrada-Madrid, Spain. 7. Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), C/ Diego de León 62, 28006, Madrid, Spain. mefdezcontreras@hotmail.com. 8. Departments of Anatomy I and Immunology, School of Medicine, Universidad Alfonso X El Sabio (UAX), Avda. de la Universidad 1, 28691, Villanueva de la Cañada, Madrid, Spain. mefdezcontreras@hotmail.com.
Abstract
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity. METHODS: Serum samples from 145 patients with IBD (79 Crohn's disease [CD] and 66 ulcerative colitis [UC]) and 39 controls were retrospectively studied. Circulating ERα and ERβ were measured by ELISA. Disease activities were assessed by clinical and endoscopic indices specific for CD and UC. RESULTS: Low values of ERβ/ERα ratio were directly associated with clinical (p = 0.019) and endoscopic (p = 0.002) disease activity. Further analyses by type of IBD confirmed a strong association between low ERβ/ERα ratio and CD clinical (p = 0.011) and endoscopic activity (p = 0.002). The receiver operating curve (ROC) analysis showed that an ERβ/ERα ratio under 0.85 was a good marker of CD endoscopic activity (area under the curve [AUC]: 0.84; p = 0.002; sensitivity: 70%; specificity: 91%). ERβ/ERα ratio was not useful to predict UC activity. CONCLUSIONS: An ERβ/ERα ratio under 0.85 indicated CD endoscopic activity. The determination of serum ERβ/ERα might be a useful noninvasive screening tool for CD endoscopic activity.
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity. METHODS: Serum samples from 145 patients with IBD (79 Crohn's disease [CD] and 66 ulcerative colitis [UC]) and 39 controls were retrospectively studied. Circulating ERα and ERβ were measured by ELISA. Disease activities were assessed by clinical and endoscopic indices specific for CD and UC. RESULTS: Low values of ERβ/ERα ratio were directly associated with clinical (p = 0.019) and endoscopic (p = 0.002) disease activity. Further analyses by type of IBD confirmed a strong association between low ERβ/ERα ratio and CD clinical (p = 0.011) and endoscopic activity (p = 0.002). The receiver operating curve (ROC) analysis showed that an ERβ/ERα ratio under 0.85 was a good marker of CD endoscopic activity (area under the curve [AUC]: 0.84; p = 0.002; sensitivity: 70%; specificity: 91%). ERβ/ERα ratio was not useful to predict UC activity. CONCLUSIONS: An ERβ/ERα ratio under 0.85 indicated CD endoscopic activity. The determination of serum ERβ/ERα might be a useful noninvasive screening tool for CD endoscopic activity.
Authors: S Kato; H Endoh; Y Masuhiro; T Kitamoto; S Uchiyama; H Sasaki; S Masushige; Y Gotoh; E Nishida; H Kawashima; D Metzger; P Chambon Journal: Science Date: 1995-12-01 Impact factor: 47.728
Authors: Wendy A Goodman; Sarah M Bedoyan; Hannah L Havran; Brian Richardson; Mark J Cameron; Theresa T Pizarro Journal: Proc Natl Acad Sci U S A Date: 2020-07-06 Impact factor: 11.205
Authors: Iwona Krela-Kaźmierczak; Marzena Skrzypczak-Zielińska; Marta Kaczmarek-Ryś; Michał Michalak; Aleksandra Szymczak-Tomczak; Szymon T Hryhorowicz; Marlena Szalata; Liliana Łykowska-Szuber; Piotr Eder; Kamila Stawczyk-Eder; Maciej Tomczak; Ryszard Słomski; Agnieszka Dobrowolska Journal: J Clin Med Date: 2019-08-24 Impact factor: 4.241