Natalia Mochalina1, Nazim Isma2, Peter J Svensson3, Anders Själander4, Maj Carlsson5, Tord Juhlin6, Mattias Wieloch3. 1. Department of Cardiology, Skåne University Hospital, S-2050 Malmö, Sweden. Electronic address: natalia.mochalina@med.lu.se. 2. Department of Cardiology, Skåne University Hospital, S-221 85 Lund, Sweden. 3. Department of Translational Medicine, Lund University, S-221 00 Lund, Sweden. 4. Department of Public Health and Clinical Medicine, Umeå University, S-901 85 Umeå, Sweden. 5. Department of Medicines Management and Informatics, Region Skåne, S-211 20 Malmö, Sweden. 6. Department of Cardiology, Skåne University Hospital Malmö, S-205 02 Malmö, Sweden.
Abstract
INTRODUCTION: The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. MATERIALS AND METHODS: Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011-2013 in primary and secondary care and receiving oral anticoagulants (n=4847), aspirin (n=2850) or no treatment (n=3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365days after AF diagnosis. RESULTS AND CONCLUSION: Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37-3.45%) to 1.93% (95% CI 1.54-2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient -0.08; 95% CI, -0.09 to -0.07, p<0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.
INTRODUCTION: The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. MATERIALS AND METHODS: Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011-2013 in primary and secondary care and receiving oral anticoagulants (n=4847), aspirin (n=2850) or no treatment (n=3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365days after AF diagnosis. RESULTS AND CONCLUSION: Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37-3.45%) to 1.93% (95% CI 1.54-2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient -0.08; 95% CI, -0.09 to -0.07, p<0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AFpatients.
Authors: Stephen B Wilton; Padma Kaul; Sunjidatul Islam; Clare L Atzema; Jennifer Cruz; Kendra MacFarlane; Robert McKelvie; Stephanie Poon; Laurie Lambert; Kathy Rush; Marc Deyell; D George Wyse; Jafna L Cox; Allan Skanes; Roopinder K Sandhu Journal: CJC Open Date: 2021-01-13
Authors: Emilio Rodríguez-Castro; Iria López-Dequit; María Santamaría-Cadavid; Susana Arias-Rivas; Manuel Rodríguez-Yáñez; José Manuel Pumar; Pablo Hervella; Esteban López-Arias; Andrés da Silva-Candal; Ana Estany; María Piñeiro-Lamas; Tomás Sobrino; Francisco Campos; Manuel Portela; Manuel Vázquez-Lima; José Castillo; Ramón Iglesias-Rey Journal: BMC Neurol Date: 2018-10-03 Impact factor: 2.474