Stefano Balducci1,2,3, Valeria D'Errico1,2,3, Jonida Haxhi1,2,3, Massimo Sacchetti4, Giorgio Orlando4, Patrizia Cardelli1,5, Martina Vitale1,2, Lucilla Bollanti1,2, Francesco Conti1,2, Silvano Zanuso6, Antonio Nicolucci7, Giuseppe Pugliese8,2. 1. Department of Clinical and Molecular Medicine, ''La Sapienza'' University, Rome, Italy. 2. Diabetes Unit, Sant'Andrea Hospital, Rome, Italy. 3. Metabolic Fitness Association, Monterotondo, Rome, Italy. 4. Department of Human Movement and Sport Sciences, ''Foro Italico'' University, Rome, Italy. 5. Laboratory of Clinical Chemistry, Sant'Andrea Hospital, Rome, Italy. 6. Center for Applied Biological and Exercise Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, U.K. 7. Center for Outcomes Research and Clinical Epidemiology (CORESEARCH), Pescara, Italy. 8. Department of Clinical and Molecular Medicine, ''La Sapienza'' University, Rome, Italy giuseppe.pugliese@uniroma1.it.
Abstract
OBJECTIVE: Adherence to physical activity (PA) recommendations is hampered by the lack of effective strategies to promote behavior change. The Italian Diabetes and Exercise Study 2 (IDES_2) is a randomized controlled trial evaluating a novel behavioral intervention strategy for increasing PA and decreasing sedentary time (SED-time) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: The study randomized 300 physically inactive and sedentary patients with type 2 diabetes 1:1 toreceive theoretical and practical counseling once yearly for 3 years (intervention group [INT]) or standard care (control group [CON]). Here, we report the 4-month effects on objectively (accelerometer) measured daily light-intensity PA (LPA), moderate-to-vigorous-intensity PA (MVPA), and SED-time, and cardiovascular risk factors. RESULTS:LPA and MVPA both increased, and SED-time decreased in both groups, although changes were significantly more marked in INT participants (approximately twofold for LPA and SED-time and approximately sixfold for MVPA). A significant reduction in HbA1c was observed only in INT subjects. An increase in LPA >0.92 h · day-1 and in MVPA >7.33 min · day-1 and a decrease in SED-time >1.05 h · day-1 were associated with an average decrease in HbA1c of ∼1% and also with significant improvements in fasting glucose, body weight, waist circumference, and hs-CRP. Changes in PA and SED-time were independent predictors of improvements in HbA1c. CONCLUSIONS: This behavioral intervention is effective in the short term for increasing LPA and MVPA and reducing SED-time. Significant improvements in cardiometabolic risk profiles were observed in subjects experiencing the most pronounced changes in PA and SED-time, even if below the recommended level.
RCT Entities:
OBJECTIVE: Adherence to physical activity (PA) recommendations is hampered by the lack of effective strategies to promote behavior change. The Italian Diabetes and Exercise Study 2 (IDES_2) is a randomized controlled trial evaluating a novel behavioral intervention strategy for increasing PA and decreasing sedentary time (SED-time) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: The study randomized 300 physically inactive and sedentary patients with type 2 diabetes 1:1 to receive theoretical and practical counseling once yearly for 3 years (intervention group [INT]) or standard care (control group [CON]). Here, we report the 4-month effects on objectively (accelerometer) measured daily light-intensity PA (LPA), moderate-to-vigorous-intensity PA (MVPA), and SED-time, and cardiovascular risk factors. RESULTS:LPA and MVPA both increased, and SED-time decreased in both groups, although changes were significantly more marked in INT participants (approximately twofold for LPA and SED-time and approximately sixfold for MVPA). A significant reduction in HbA1c was observed only in INT subjects. An increase in LPA >0.92 h · day-1 and in MVPA >7.33 min · day-1 and a decrease in SED-time >1.05 h · day-1 were associated with an average decrease in HbA1c of ∼1% and also with significant improvements in fasting glucose, body weight, waist circumference, and hs-CRP. Changes in PA and SED-time were independent predictors of improvements in HbA1c. CONCLUSIONS: This behavioral intervention is effective in the short term for increasing LPA and MVPA and reducing SED-time. Significant improvements in cardiometabolic risk profiles were observed in subjects experiencing the most pronounced changes in PA and SED-time, even if below the recommended level.
Authors: Zixin Zeng; Yuqian Bian; Yiran Cui; Donghui Yang; Yafeng Wang; Chuanhua Yu Journal: Int J Environ Res Public Health Date: 2020-10-25 Impact factor: 3.390
Authors: Nyssa T Hadgraft; Elisabeth Winkler; Rachel E Climie; Megan S Grace; Lorena Romero; Neville Owen; David Dunstan; Genevieve Healy; Paddy C Dempsey Journal: Br J Sports Med Date: 2020-04-08 Impact factor: 13.800