Daphnauranins A and B, two new antifeedants Isolated from Daphne aurantiaca roots.

Daphnauranins A (1) and B (2), two sesquiterpenoids were isolated from the roots of Daphne aurantiaca Diels. One is an unprecedented 5/7 oxacycloheptane ring system, the other is a sesquiterpene-lignan complex. Their structures were elucidated by comprehensive spectroscopic methods including MS and NMR. Their absolute configurations were further confirmed by the quantum ECD calculations. Daphnauranins A and B showed anti-insect activities against male fruit fly with anti-feeding rate up to 46.2±7.1 and 44.7±5.4% at 1mM, respectively.