Literature DB >> 28820207

Condensing the information in DNA with double-headed nucleotides.

Mick Hornum1, Pawan K Sharma, Charlotte Reslow-Jacobsen, Pawan Kumar, Michael Petersen, Poul Nielsen.   

Abstract

A normal duplex holds as many Watson-Crick base pairs as the number of nucleotides in its constituent strands. Here we establish that single nucleotides can be designed to functionally imitate dinucleotides without compromising binding affinity. This effectively allows sequence information to be more compact and concentrated to fewer phosphates.

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Year:  2017        PMID: 28820207     DOI: 10.1039/c7cc05047j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition.

Authors:  Kasper M Beck; Marie B Krogh; Mick Hornum; Paul T Ludford; Yitzhak Tor; Poul Nielsen
Journal:  Org Biomol Chem       Date:  2020-09-23       Impact factor: 3.876

  1 in total

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