Yuan Wang 1 , Quan Yuan 1 , Liang Xie 1 Show Affiliations »
Abstract
BACKGROUND: Aging is characterized by time-dependent functional decline, which results in the reduced ability to cope with physiological challenges. The aging process can be affected by genetic factors, environment factors, epigenetic factors, and several stochastic factors. Epigenetic marker alteration during aging has been widely monitored and studied recently, since these epigenetic alterations are theoretically reversible. OBJECTIVES: In this review, we will elaborate on the connection between aging and histone modifications, mainly focusing on the major modification participated in aging and its underlying mechanism. We will also summarize the latest research progress of the potential and promising treatments or strategies that aim to reverse aging through the intervention of histone modifications. CONCLUSION: Histone post-translational modifications play a crucial role in epigenetic alteration during aging, among which histone methylation and histone acetylation are emerging as two prominent modification methods. These modifications can serve as the therapeutic targets in the pursuit of rejuvenation. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Aging is characterized by time-dependent functional decline, which results in the reduced ability to cope with physiological challenges. The aging process can be affected by genetic factors, environment factors, epigenetic factors, and several stochastic factors. Epigenetic marker alteration during aging has been widely monitored and studied recently, since these epigenetic alterations are theoretically reversible. OBJECTIVES: In this review, we will elaborate on the connection between aging and histone modifications, mainly focusing on the major modification participated in aging and its underlying mechanism. We will also summarize the latest research progress of the potential and promising treatments or strategies that aim to reverse aging through the intervention of histone modifications. CONCLUSION: Histone post-translational modifications play a crucial role in epigenetic alteration during aging, among which histone methylation and histone acetylation are emerging as two prominent modification methods. These modifications can serve as the therapeutic targets in the pursuit of rejuvenation. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Keywords:
Aging; epigenetics; histone acetylation; histone methylation; histone modification; rejuvenation
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Year: 2018
PMID： 28820059 DOI： 10.2174/1574888X12666170817141921
Source DB: PubMed Journal: Curr Stem Cell Res Ther ISSN： 1574-888X Impact factor: 3.828