| Literature DB >> 2882001 |
R K Goel, N K Pathak, M Biswas, V B Pandey, A K Sanyal.
Abstract
Lapachol, a naphthaquinone isolated from the roots of Tectona grandis given at a dose of 5 mg kg-1 p.o. twice daily for 3 days was found to have an anti-ulcerogenic effect on subsequently induced experimental gastric and duodenal ulcers in rats and guinea-pigs. Its action appears to be associated with an effect on the protein content of gastric juice, and it reversed aspirin-induced changes in peptic activity, protein and sialic acid.Entities:
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Year: 1987 PMID： 2882001 DOI： 10.1111/j.2042-7158.1987.tb06962.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765