Chikako Oyabu1, Emi Ushigome1, Shinobu Matsumoto1, Toru Tanaka2, Goji Hasegawa3, Naoto Nakamura4, Masayoshi Ohnishi5, Sei Tsunoda6, Hidetaka Ushigome7, Isao Yokota8, Muhei Tanaka1, Mai Asano1, Masahiro Yamazaki1, Michiaki Fukui1. 1. 1 Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 2. 2 Department of Endocrinology and Metabolism, Kyoto First Red Cross Hospital, Kyoto, Japan. 3. 3 Department of Endocrinology and Metabolism, Kyoto Second Red Cross Hospital, Kyoto, Japan. 4. 4 Saiseikai Kyoto Hospital, Kyoto, Japan. 5. 5 Department of Endocrinology and Metabolism, Osaka General Hospital of West Japan Railway Company, Osaka, Japan. 6. 6 Nishijin Hospital, Kyoto, Japan. 7. 7 Department of Organ Transplantation and General Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 8. 8 Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Abstract
OBJECTIVE: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes. METHODS: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr). RESULTS: Multivariate linear regression analyses indicated that mean morning systolic blood pressure ( β = 0.010, p < 0.001) and maximum morning systolic blood pressure ( β = 0.008, p < 0.001) were significantly associated with urine albumin to creatinine ratio. Area under the receiver operating characteristic curve (95% confidence interval) for diabetic nephropathy in mean and maximum morning systolic blood pressure was 0.667 (0.634-0.700; p < 0.001) and 0.671 (0.638-0.703; p < 0.001), respectively. CONCLUSION: Maximum home systolic blood pressure, as well as mean home systolic blood pressure, was significantly associated with diabetic nephropathy in patients with type 2 diabetes.
OBJECTIVE: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes. METHODS: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr). RESULTS: Multivariate linear regression analyses indicated that mean morning systolic blood pressure ( β = 0.010, p < 0.001) and maximum morning systolic blood pressure ( β = 0.008, p < 0.001) were significantly associated with urine albumin to creatinine ratio. Area under the receiver operating characteristic curve (95% confidence interval) for diabetic nephropathy in mean and maximum morning systolic blood pressure was 0.667 (0.634-0.700; p < 0.001) and 0.671 (0.638-0.703; p < 0.001), respectively. CONCLUSION: Maximum home systolic blood pressure, as well as mean home systolic blood pressure, was significantly associated with diabetic nephropathy in patients with type 2 diabetes.
Entities:
Keywords:
Maximum home blood pressure; diabetic nephropathy; home blood pressure monitoring; hypertension; multicenter study; type 2 diabetes
Authors: Thineskrishna Anbarasan; Amy Rogers; David A Rorie; J W Kerr Grieve; Robert W V Flynn; Thomas M MacDonald; Isla S Mackenzie Journal: J Hum Hypertens Date: 2021-03-02 Impact factor: 3.012