Literature DB >> 2881883

A new polymorphic marker of the T-cell antigen receptor alpha chain genes in man.

A So, S John, C Bailey, M J Owen.   

Abstract

The restriction fragment length polymorphism of the unrearranged T-cell antigen receptor (Tcr) alpha chain gene was investigated. Taq I digests, when probed with a Tcr alpha chain cDNA probe, revealed polymorphic bands of 7.0, 2.0, and 1.4 kb, due to variations around the C alpha gene, and the V gene cluster. Family studies confirmed the segregation of these polymorphic bands as allelic markers. These polymorphisms provide a new marker for the analysis of genetic variation of the Tcr alpha chain, and the influence of variation of the Tcr genes on the immune response.

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Year:  1987        PMID： 2881883     DOI： 10.1007/bf00344026

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  10 in total

Review 1.  A speculative view of the multicomponent nature of T cell antigen recognition.

Authors:  J Goverman; T Hunkapiller; L Hood
Journal:  Cell       Date:  1986-05-23       Impact factor: 41.582

2.  Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain.

Authors:  Y Yoshikai; S P Clark; S Taylor; U Sohn; B I Wilson; M D Minden; T W Mak
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

3.  Molecular determination of T-cell receptor alpha and beta chain genotypes in human families.

Authors:  M A Robinson; T J Kindt
Journal:  Hum Immunol       Date:  1985-11       Impact factor: 2.850

4.  Rearrangements of T cell receptor loci can be found only rarely in B lymphoid cells.

Authors:  A Traunecker; M Kiefer; Z Dembić; M Steinmetz; K Karjalainen
Journal:  Eur J Immunol       Date:  1986-04       Impact factor: 5.532

Review 5.  The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition.

Authors:  M Kronenberg; G Siu; L E Hood; N Shastri
Journal:  Annu Rev Immunol       Date:  1986       Impact factor: 28.527

Review 6.  Molecular genetics of the T cell-receptor beta chain.

Authors:  M M Davis
Journal:  Annu Rev Immunol       Date:  1985       Impact factor: 28.527

7.  Regulation of T-cell receptor gene expression in human T-cell development.

Authors:  M K Collins; G Tanigawa; A M Kissonerghis; M Ritter; K M Price; S Tonegawa; M J Owen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

8.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

9.  Primary structure of human T-cell receptor alpha-chain.

Authors:  G K Sim; J Yagüe; J Nelson; P Marrack; E Palmer; A Augustin; J Kappler
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

10.  Segregation of polymorphic T-cell receptor genes in human families.

Authors:  M A Robinson; T J Kindt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205
  10 in total
  6 in total

1.  T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

Authors:  J R Oksenberg; M Sherritt; A B Begovich; H A Erlich; C C Bernard; L L Cavalli-Sforza; L Steinman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

2.  A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases.

Authors:  M Timón; A Arnaiz-Villena; P Pérez-Aciego; P Morales; D Benmamar; J R Regueiro
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

3.  Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci.

Authors:  A G Demaine; S Ratanachaiyavong; R Pope; D Ewins; B A Millward; A M McGregor
Journal:  Clin Exp Immunol       Date:  1989-07       Impact factor: 4.330

4.  Genetic recombination within the human T-cell receptor alpha-chain gene complex.

Authors:  M A Robinson; T J Kindt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

5.  T-cell receptor genes and insulin-dependent diabetes mellitus (IDDM): no evidence for linkage from affected sib pairs.

Authors:  P Concannon; J A Wright; L G Wright; D R Sylvester; R S Spielman
Journal:  Am J Hum Genet       Date:  1990-07       Impact factor: 11.025

6.  The V gamma locus of the human T cell receptor gamma gene. Repertoire polymorphism of the first variable gene segment subgroup.

Authors:  M P Font; Z Chen; J C Bories; N Duparc; P Loiseau; L Degos; H Cann; D Cohen; J Dausset; F Sigaux
Journal:  J Exp Med       Date:  1988-10-01       Impact factor: 14.307
  6 in total

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