| Literature DB >> 28816454 |
Jianguang Zhou1, Qun Jiang1, Peng Fu1, Siqian Liu1, Sisi Zhang1, Su Xu1, Qi Zhang1.
Abstract
An alternative synthesis of 4-(heteroaryl)cyclohexanones is described featuring a palladium-catalyzed ester α-arylation followed by decarboxylation. The substrate scope is broad with a wide range of heteroaryl halides. In particular, the reaction robustness is demonstrated by the synthesis of >10 g of 4-(pyrazin-2-yl)cyclohexanone with 85% overall yield.Entities:
Year: 2017 PMID： 28816454 DOI： 10.1021/acs.joc.7b01443
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354