Literature DB >> 28815578

IL-17 polarization of MAIT cells is derived from the activation of two different pathways.

Giuliana Guggino1, Diana Di Liberto2, Marianna Lo Pizzo2, Laura Saieva3, Riccardo Alessandro3, Francesco Dieli2, Giovanni Triolo1, Francesco Ciccia1.   

Abstract

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  IL-17; IL-23; IL-7; MAIT cells; RORc; STAT3; Sjogren's Syndrome

Mesh：

Substances：

Year:  2017        PMID： 28815578     DOI： 10.1002/eji.201747140

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  13 in total

1. 

Authors:  渊 任; 戈丹 崔; 永翔 高
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Review 2.  Research progress on inflammatory mechanism of primary Sjögren syndrome.

Authors:  Yuan Ren; Gedan Cui; Yongxiang Gao
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Review 3.  MAIT cells and their implication in human oral diseases.

Authors:  Qin Jiang; Fang Wang; Jing-Ya Yang; Gang Zhou
Journal:  Inflamm Res       Date:  2022-07-04       Impact factor: 6.986

4.  Transcriptional profiling reveals gland-specific differential expression in the three major salivary glands of the adult mouse.

Authors:  Xin Gao; Maria S Oei; Catherine E Ovitt; Murat Sincan; James E Melvin
Journal:  Physiol Genomics       Date:  2018-01-26       Impact factor: 3.107

Review 5.  MAIT cells and microbial immunity.

Authors:  Erin W Meermeier; Melanie J Harriff; Elham Karamooz; David M Lewinsohn
Journal:  Immunol Cell Biol       Date:  2018-03-09       Impact factor: 5.126

Review 6.  Mucosal-associated invariant T cells and disease.

Authors:  Amine Toubal; Isabelle Nel; Sophie Lotersztajn; Agnès Lehuen
Journal:  Nat Rev Immunol       Date:  2019-10       Impact factor: 53.106

7.  Salivary gland immunization via Wharton's duct activates differential T-cell responses within the salivary gland immune system.

Authors:  Guangliang Liu; Fangfang Zhang; Ruixue Wang; Steven D London; Lucille London
Journal:  FASEB J       Date:  2019-02-28       Impact factor: 5.834

8.  Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response.

Authors:  Maya Hassane; Youenn Jouan; Florent Creusat; Daphnée Soulard; Chloé Boisseau; Loïc Gonzalez; Emmanuel C Patin; Nathalie Heuzé-Vourc'h; Jean-Claude Sirard; Christelle Faveeuw; François Trottein; Mustapha Si-Tahar; Thomas Baranek; Christophe Paget
Journal:  Mucosal Immunol       Date:  2019-10-18       Impact factor: 7.313

Review 9.  MAIT Cells and Microbiota in Multiple Sclerosis and Other Autoimmune Diseases.

Authors:  Rosella Mechelli; Silvia Romano; Carmela Romano; Emanuele Morena; Maria Chiara Buscarinu; Rachele Bigi; Gianmarco Bellucci; Roberta Reniè; Giulia Pellicciari; Marco Salvetti; Giovanni Ristori
Journal:  Microorganisms       Date:  2021-05-24

10.  Mapping Salivary Proteases in Sjögren's Syndrome Patients Reveals Overexpression of Dipeptidyl Peptidase-4/CD26.

Authors:  Laís Garreto; Sébastien Charneau; Samuel Coelho Mandacaru; Otávio T Nóbrega; Flávia N Motta; Carla N de Araújo; Audrey C Tonet; Flávia M B Modesto; Lilian M Paula; Marcelo Valle de Sousa; Jaime M Santana; Ana Carolina Acevedo; Izabela M D Bastos
Journal:  Front Immunol       Date:  2021-06-17       Impact factor: 7.561
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