Literature DB >> 2881542

Sulfated oligosaccharides in human lysosomal enzymes.

T Braulke, A Hille, W B Huttner, A Hasilik, K von Figura.   

Abstract

Cathepsin D, arylsulfatase A and the alpha-chain of beta-hexosaminidase are synthesized in human fibroblasts as sulfated polypeptides. The sulfate is added posttranslationally. Its half-life is less than one-tenth of that of the respective polypeptide chains. The sulfate residues were found on asparagine-linked oligosaccharides sensitive to endoglycosidase F and peptide: N-glycosidase F and resistant to endoglycosidase H. Inhibition of formation of complex type oligosaccharides by 1-deoxy-manno-nojirimycin prevented sulfation, indicating that the sulfate residues were added to complex type oligosaccharides.

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Year:  1987        PMID： 2881542     DOI： 10.1016/0006-291x(87)90647-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

Review 1.  The early and late processing of lysosomal enzymes: proteolysis and compartmentation.

Authors:  A Hasilik
Journal:  Experientia       Date:  1992-02-15

2.  Binding of synthetic sulfated ligands by human splenic galectin 1, a beta-galactoside-binding lectin.

Authors:  H J Allen; H Ahmed; K L Matta
Journal:  Glycoconj J       Date:  1998-07       Impact factor: 2.916

3.  N-linked Glycan Release Efficiency: A Quantitative Comparison between NaOCl and PNGase F Release Protocols.

Authors:  David A Fischler; Ron Orlando
Journal:  J Biomol Tech       Date:  2019-12

4.  The structural basis for the electrophoretic isoforms of normal and variant human platelet arylsulphatase A.

Authors:  R D Poretz; R S Yang; B Canas; H Lackland; S Stein; P Manowitz
Journal:  Biochem J       Date:  1992-11-01       Impact factor: 3.857

5.  Metabolic actions of insulin-like growth factor II in cultured adult rat hepatocytes are not mediated through the insulin-like growth factor II receptor.

Authors:  H Hartmann; A Meyer-Alber; T Braulke
Journal:  Diabetologia       Date:  1992-03       Impact factor: 10.122

6.  Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.

Authors:  A Shilatifard; R K Merkle; D E Helland; J L Welles; W A Haseltine; R D Cummings
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103
  6 in total

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