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Literature DB >> 2881536

Covalently bound pyrroloquinoline quinone is the organic prosthetic group in human placental lysyl oxidase.

Abstract

Treatment of purified human placental lysyl oxidase with 2,4-dinitrophenylhydrazine (DNPH) resulted in a large spectral change and inhibition of enzyme activity. Proteolytic degradation of the derivatized enzyme yielded only one single coloured product, which was spectrally and chromatographically identical with the C-5 hydrazone of PQQ (pyrroloquinoline quinone) and DNPH. Since this represents the first example of a PQQ-containing enzyme in man, possible implications of the finding are discussed.

Entities: Chemical Species

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Year: 1986 PMID： 2881536 PMCID： PMC1147358 DOI： 10.1042/bj2390789

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

13 in total

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

2. Stability and purification of lysyl oxidase.

Authors: A S Narayanan; R C Siegel; G R Martin
Journal: Arch Biochem Biophys Date: 1974-05 Impact factor: 4.013

Review 3. Enzymology of quinoproteins.

Authors: J A Duine; J Frank; J A Jongejan
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1987

Review 4. Lysyl oxidase.

Authors: R C Siegel
Journal: Int Rev Connect Tissue Res Date: 1979

5. Use of triazine dyes in the affinity chromatographic purification of alkaline phosphatase from calf intestine.

Authors: V Bouriotis; P D Dean
Journal: J Chromatogr Date: 1981-02-27

6. Purification and properties of four species of lysyl oxidase from bovine aorta.

Authors: H M Kagan; K A Sullivan; T A Olsson; A L Cronlund
Journal: Biochem J Date: 1979-01-01 Impact factor: 3.857

7. Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile.

Authors: R C Page; E P Benditt
Journal: Biochemistry Date: 1967-04 Impact factor: 3.162

8. Human placental lysyl oxidase. Purification, partial characterization, and preparation of two specific antisera to the enzyme.

Authors: H Kuivaniemi; E R Savolainen; K I Kivirikko
Journal: J Biol Chem Date: 1984-06-10 Impact factor: 5.157

9. Bovine serum amine oxidase: a mammalian enzyme having covalently bound PQQ as prosthetic group.

Authors: C L Lobenstein-Verbeek; J A Jongejan; J Frank; J A Duine
Journal: FEBS Lett Date: 1984-05-21 Impact factor: 4.124

10. Reaction of aortic lysyl oxidase with beta-aminopropionitrile.

Authors: S S Tang; P C Trackman; H M Kagan
Journal: J Biol Chem Date: 1983-04-10 Impact factor: 5.157

10 in total

1. Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture.

Authors: G Tschank; M Raghunath; V Günzler; H M Hanauske-Abel
Journal: Biochem J Date: 1987-12-15 Impact factor: 3.857

Covalently bound pyrroloquinoline quinone is the organic prosthetic group in human placental lysyl oxidase.

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

2. Stability and purification of lysyl oxidase.

Review 3. Enzymology of quinoproteins.

Review 4. Lysyl oxidase.

5. Use of triazine dyes in the affinity chromatographic purification of alkaline phosphatase from calf intestine.

6. Purification and properties of four species of lysyl oxidase from bovine aorta.

7. Molecular diseases of connective and vascular tissues. II. Amine oxidase inhibition by the lathyrogen, beta-aminopropionitrile.

8. Human placental lysyl oxidase. Purification, partial characterization, and preparation of two specific antisera to the enzyme.

9. Bovine serum amine oxidase: a mammalian enzyme having covalently bound PQQ as prosthetic group.

10. Reaction of aortic lysyl oxidase with beta-aminopropionitrile.

1. Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture.

2. Purification of lysyl oxidase from piglet skin by selective interaction with Sephacryl S-200.

3. Production of pyrroloquinoline quinone by using methanol-utilizing bacteria.

Review 4. PQQ and quinoproteins: an important novel field in enzymology.

Review 5. Schiff base forming drugs: mechanisms of immune potentiation and therapeutic potential.

6. Factors affecting the production of pyrroloquinoline quinone by the methylotrophic bacterium W3A1.

7. PQQ: biosynthetic studies in Methylobacterium AM1 and Hyphomicrobium X using specific 13C labeling and NMR.

8. Steady-state kinetic analysis of the quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

9. Levels of pyrroloquinoline quinone in various foods.

10. Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution.